Rad51C Antibody (F-11): sc-390697

Rad51C Antibody (F-11) is a mouse monoclonal IgG1 kappa light chain antibody designed to target the N-terminal region (amino acids 1-157) of the human Rad51C protein, ensuring precise detection across multiple applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) in mouse, rat, and human samples. Rad51C, also called R51H3 and Rad51l2a, is a vital member of the Rad51 paralog family, primarily localized in the nucleus, where Rad51C plays an essential role in the homologous recombination repair pathway responsible for fixing DNA double-strand breaks. This nuclear localization is crucial because Rad51C has direct access to the genomic DNA, facilitating accurate and efficient repair processes that maintain genomic stability and prevent mutations that could lead to cancer. Rad51C functions by forming complexes with other Rad51 paralogs such as Rad51B, Rad51D, XRCC2, and XRCC3, creating the BCDX2 and CX3 complexes that are integral to the detection and repair of DNA damage. These interactions are essential for orchestrating the homologous recombination machinery, ensuring that DNA breaks are repaired correctly and timely. Additionally, Rad51C collaborates with key proteins like BRCA1 and BRCA2, which are critical for the DNA damage response and repair mechanisms, thereby enhancing the cell′s ability to maintain genomic integrity. The precise regulation and nuclear presence of Rad51C underscore its importance in safeguarding against genomic instability and tumorigenesis. Rad51C (F-11) monoclonal antibody exhibits high specificity with no cross-reactivity against other Rad51 family members, providing reliable and accurate results for researchers investigating DNA repair pathways, cancer biology, and genomic integrity. Rad51C (F-11) antibody is available in both non-conjugated form and various conjugated forms including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Anti-Rad51C antibody (F-11) is recommended for researchers studying the molecular mechanisms underlying DNA repair, understanding the pathways that maintain genomic integrity, and advancing research into cancer development and potential therapeutic interventions.

The preferred Rad51C antibody is Rad51C Antibody (2H11): sc-56214.