Rad21 Antibody (H-12): sc-166973
- Rad21 Antibody (H-12) is a mouse monoclonal IgG2b κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 143-352 mapping within an internal region of Rad21 of human origin
- recommended for detection of Rad21 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Rad21 Antibody (H-12) for WB applications. These reagents are now offered in bundles with Rad21 Antibody (H-12) (see ordering information below).
Rad21 Antibody (H-12) is a mouse monoclonal IgG2b antibody that detects Rad21 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rad21 is a crucial component of the cohesin complex, which plays a vital role in holding sister chromatids together until anaphase, ensuring accurate chromosome segregation during cell division. anti-Rad21 antibody (H-12) is essential for studying genomic stability and mitotic growth, as Rad21 participates in repairing double-strand breaks in DNA. Rad21 undergoes a C-terminal cleavage in response to various stimuli just prior to apoptosis, resulting in a cleavage product that translocates to the cytoplasm and participates in the early stages of the apoptotic pathway, thereby amplifying the cell death signal in a positive-feedback loop. Furthermore, the RAD21 gene has been implicated in the invasion and metastasis of cancer cells, positioning Rad21 as a potential target for cancer therapeutics aimed at enhancing the efficacy of chemotherapeutic agents that induce DNA damage. With multifaceted roles in cell cycle regulation and apoptosis, Rad21 monoclonal antibody (H-12) serves as a valuable tool for researchers investigating the mechanisms of cell division and cancer progression.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rad21 Antibody (H-12) | sc-166973 | 200 µg/ml | $322.00 | |||
Rad21 Antibody (H-12): m-IgG Fc BP-HRP Bundle | sc-537554 | 200 µg Ab; 10 µg BP | $361.00 | |||
Rad21 Antibody (H-12): m-IgGκ BP-HRP Bundle | sc-534852 | 200 µg Ab; 40 µg BP | $361.00 |