Rad17 Antibody (1C6/2): sc-53427

Rad17 Antibody (1C6/2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rad17 protein of yeast origin by western blotting (WB). Rad17 plays a crucial role in the DNA damage response, particularly in the activation of cell cycle checkpoints that ensure the integrity of genetic material during cell division. Rad17 is essential for the proper functioning of the G1 and G2 checkpoints, which are critical for preventing the replication of damaged DNA. Rad17 interacts with other key proteins such as Rad9, Rad24, and Mec3, forming a complex that is vital for checkpoint activation. Additionally, anti-Rad17 antibody (1C6/2) recognizes interactions with protein kinase Rad53, which is necessary for both G2 and S phase arrest, highlighting Rad17′s importance in the cellular response to DNA damage. The regulation of Rad53 by Mec1, a homolog of the human ATM protein, further emphasizes the evolutionary conservation of these mechanisms across species. Rad17 (1C6/2) antibody enables researchers to gain valuable insights into the molecular pathways that maintain genomic stability and understand the implications of DNA damage in various biological contexts.

The preferred Rad17 antibody is Rad17 Antibody (H-3): sc-17761.