Rab 34 Antibody (H-6): sc-376898

Rab 34 Antibody (H-6) is a mouse monoclonal IgG1 antibody that detects Rab 34 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rab 34 is a member of the Rab family of small GTPases, which play a crucial role in intracellular membrane trafficking, particularly in the regulation of vesicle transport. Rab 34 is primarily located in the cytoplasm and is involved in the transport of vesicles from the Golgi apparatus to the plasma membrane, a process essential for maintaining cellular homeostasis and facilitating communication between cells. Proper functioning of Rab 34 is vital, as disruptions in its activity can lead to various diseases, including neurodegenerative disorders and cancer, highlighting its importance in both normal physiology and disease states. Rab 34 interacts with specific effector proteins that mediate the docking and fusion of transport vesicles with target membranes, ensuring that proteins and lipids are delivered accurately to their destinations within the cell. Anti-Rab 34 antibody (H-6) is an invaluable tool for researchers studying the dynamics of vesicular transport and the role of Rab proteins in cellular processes.

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Rab 34 Antibody (H-6) References:

1. Rab39, a novel Golgi-associated Rab GTPase from human dendritic cells involved in cellular endocytosis.  |  Chen, T., et al. 2003. Biochem Biophys Res Commun. 303: 1114-20. PMID: 12684051
2. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.  |  Yoshimura, S., et al. 2010. J Cell Biol. 191: 367-81. PMID: 20937701
3. Preference in the nodulation of Phaseolus vulgaris cv. RAB39. II. Effect of delayed inoculation or low cell representation in the inoculant on nodule occupancy by Rhizobium tropici UMR1899.  |  Montealegre, C. and Graham, PH. 1996. Can J Microbiol. 42: 844-50. PMID: 22049998
4. The most prevalent genetic cause of ALS-FTD, C9orf72 synergizes the toxicity of ATXN2 intermediate polyglutamine repeats through the autophagy pathway.  |  Ciura, S., et al. 2016. Autophagy. 12: 1406-8. PMID: 27245636
5. Staccato/Unc-13-4 controls secretory lysosome-mediated lumen fusion during epithelial tube anastomosis.  |  Caviglia, S., et al. 2016. Nat Cell Biol. 18: 727-39. PMID: 27323327
6. C9ORF72 is a GDP/GTP exchange factor for Rab8 and Rab39 and regulates autophagy.  |  Corbier, C. and Sellier, C. 2017. Small GTPases. 8: 181-186. PMID: 27494456
7. Defects in COG-Mediated Golgi Trafficking Alter Endo-Lysosomal System in Human Cells.  |  D'Souza, Z., et al. 2019. Front Cell Dev Biol. 7: 118. PMID: 31334232
8. Drosophila Rab39 Attenuates Lysosomal Degradation.  |  Lakatos, Z., et al. 2021. Int J Mol Sci. 22: PMID: 34638976
9. Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells.  |  Matsui, T., et al. 2022. Cell Rep. 39: 110875. PMID: 35649370
10. A Rab39-Klp98A-Rab35 endocytic recycling pathway is essential for rapid Golgi-dependent furrow ingression.  |  Miao, H., et al. 2023. Development. 150: PMID: 37590130

The preferred Rab 34 antibody is Rab 34 Antibody (C-5): sc-376710.