Rab 3 GAP p130 Antibody (B-8): sc-398354
- Rab 3 GAP p130 Antibody (B-8) is a mouse monoclonal IgG1 κ Rab 3 GAP p130 antibody provided at 200 µg/ml
- raised against amino acids 935-981 mapping at the C-terminus of Rab 3 GAP p130 of human origin
- Rab 3 GAP p130 Antibody (B-8) is recommended for detection of Rab 3 GAP p130 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Rab 3 GAP p130 Antibody (B-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Rab 3 GAP p130 Antibody (B-8) for WB applications. These reagents are now offered in bundles with Rab 3 GAP p130 Antibody (B-8) (see ordering information below).
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Rab 3 GAP p130 Antibody (B-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rab 3 GAP p130 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rab 3 GAP p130 (B-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Rab 3 GAP p130, also known as Rab3 GTPase-activating protein catalytic subunit, is a crucial 981 amino acid protein that plays a significant role in regulating neurotransmitter and hormone exocytosis. Specifically, Rab 3 GAP p130 functions by converting active RAB3-GTP to inactive RAB3-GDP, which is essential for maintaining proper synaptic function and neurodevelopment. Rab 3 GAP p130 is particularly important in eye and brain development, as defects in this protein are linked to Warburg micro syndrome 1 (WARBM1), a severe autosomal recessive disorder characterized by developmental abnormalities in the eye and central nervous system, as well as microgenitalia. Rab 3 GAP p130′s involvement in neurodevelopmental processes, such as cellular proliferation, migration, and differentiation prior to synapse formation, highlights its critical role in ensuring normal neurological function. Additionally, Rab 3 GAP p130 is conserved across various species, including chimpanzees, dogs, cows, mice, chickens, zebrafish, and fruit flies, and is located on human chromosome 2q21.3, underscoring its evolutionary significance.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rab 3 GAP p130 Antibody (B-8) | sc-398354 | 200 µg/ml | $316.00 | |||
Rab 3 GAP p130 Antibody (B-8): m-IgG Fc BP-HRP Bundle | sc-530769 | 200 µg Ab; 10 µg BP | $354.00 | |||
Rab 3 GAP p130 Antibody (B-8): m-IgGκ BP-HRP Bundle | sc-524306 | 200 µg Ab, 40 µg BP | $354.00 | |||
Rab 3 GAP p130 Antibody (B-8): m-IgG1 BP-HRP Bundle | sc-544243 | 200 µg Ab; 20 µg BP | $354.00 | |||
Rab 3 GAP p130 Antibody (B-8) AC | sc-398354 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Rab 3 GAP p130 Antibody (B-8) HRP | sc-398354 HRP | 200 µg/ml | $316.00 | |||
Rab 3 GAP p130 Antibody (B-8) FITC | sc-398354 FITC | 200 µg/ml | $330.00 | |||
Rab 3 GAP p130 Antibody (B-8) PE | sc-398354 PE | 200 µg/ml | $343.00 | |||
Rab 3 GAP p130 Antibody (B-8) Alexa Fluor® 488 | sc-398354 AF488 | 200 µg/ml | $357.00 | |||
Rab 3 GAP p130 Antibody (B-8) Alexa Fluor® 546 | sc-398354 AF546 | 200 µg/ml | $357.00 | |||
Rab 3 GAP p130 Antibody (B-8) Alexa Fluor® 594 | sc-398354 AF594 | 200 µg/ml | $357.00 | |||
Rab 3 GAP p130 Antibody (B-8) Alexa Fluor® 647 | sc-398354 AF647 | 200 µg/ml | $357.00 | |||
Rab 3 GAP p130 Antibody (B-8) Alexa Fluor® 680 | sc-398354 AF680 | 200 µg/ml | $357.00 | |||
Rab 3 GAP p130 Antibody (B-8) Alexa Fluor® 790 | sc-398354 AF790 | 200 µg/ml | $357.00 |