QTRTD1 Antibody (D-5): sc-393474

QTRTD1 Antibody (D-5) is a mouse monoclonal IgG2a antibody that detects QTRTD1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). QTRTD1, or queuine tRNA-ribosyltransferase domain containing 1, is a 415 amino acid protein crucial for tRNA modification and the biosynthesis of queuosine, a modified nucleoside that plays a significant role in the proper functioning of tRNA molecules. QTRTD1 is primarily located in the cytoplasm and also associates with the mitochondrial outer membrane, where QTRTD1 forms an active complex with QTRT1, facilitating the exchange of queuine for guanine at the wobble position of tRNAs with GUN anticodons. The presence of queuosine is essential for the accuracy of protein synthesis, as queuosine influences the decoding of mRNA and the overall efficiency of translation. QTRTD1 is part of the queuine tRNA-ribosyltransferase family and is encoded by a gene located on human chromosome 3, which is associated with various genetic diseases, including Marfan Syndrome and von Hippel-Lindau syndrome. anti-QTRTD1 antibody (D-5) is an invaluable tool for researchers studying tRNA modifications and their implications in cellular processes and disease mechanisms.

The preferred QTRTD1 antibody is QTRTD1 Antibody (E-4): sc-515572.