QTRTD1 Antibody (E-4): sc-515572
- QTRTD1 Antibody (E-4) is a mouse monoclonal IgG1 κ QTRTD1 antibody provided at 200 µg/ml
- raised against amino acids 183-356 mapping within an internal region of QTRTD1 of human origin
- QTRTD1 Antibody (E-4) is recommended for detection of QTRTD1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-QTRTD1 Antibody (E-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for QTRTD1 Antibody (E-4) for WB applications. These reagents are now offered in bundles with QTRTD1 Antibody (E-4) (see ordering information below).
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QTRTD1 Antibody (E-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects QTRTD1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). QTRTD1 (E-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. QTRTD1 protein, or queuine tRNA-ribosyltransferase domain containing 1, is a crucial 415 amino acid enzyme involved in the modification of transfer RNA (tRNA) and the biosynthesis of queuosine, a modified nucleoside that plays a significant role in the proper functioning of tRNA. QTRTD1 protein is primarily located in the cytoplasm and the mitochondrial outer membrane, where QTRTD1 interacts with QTRT1 to form an active queuine tRNA-ribosyltransferase complex. QTRTD1′s ability to exchange queuine for guanine at the wobble position of tRNAs with GUN anticodons is vital for maintaining the fidelity of protein synthesis, as queuosine modification enhances the stability and efficiency of tRNA. Additionally, QTRTD1 is part of the queuine tRNA-ribosyltransferase family and is encoded by a gene located on human chromosome 3, which is associated with various genetic diseases, including Marfan Syndrome and osteogenesis imperfecta, highlighting QTRTD1′s importance in both cellular function and human health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
QTRTD1 Antibody (E-4) References:
- The molecular genetics of Marfan syndrome and related microfibrillopathies. | Robinson, PN. and Godfrey, M. 2000. J Med Genet. 37: 9-25. PMID: 10633129
- Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome. | Maho, A., et al. 1999. Cytogenet Cell Genet. 87: 265-8. PMID: 10702689
- [New tumor suppressor genes in hot spots of human chromosome 3: new methods of identification]. | Braga, EA., et al. 2003. Mol Biol (Mosk). 37: 194-211. PMID: 12723467
- Uptake of genetic testing and long-term tumor surveillance in von Hippel-Lindau disease. | Rasmussen, A., et al. 2010. BMC Med Genet. 11: 4. PMID: 20064270
- Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure. | Chen, YC., et al. 2010. RNA. 16: 958-68. PMID: 20354154
- A second locus for Marfan syndrome maps to chromosome 3p24.2-p25. | Collod, G., et al. 1994. Nat Genet. 8: 264-8. PMID: 7632217
- Mutilating neuropathic ulcerations in a chromosome 3q13-q22 linked Charcot-Marie-Tooth disease type 2B family. | De Jonghe, P., et al. 1997. J Neurol Neurosurg Psychiatry. 62: 570-3. PMID: 9219740
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
QTRTD1 Antibody (E-4) | sc-515572 | 200 µg/ml | $316.00 | |||
QTRTD1 Antibody (E-4): m-IgG Fc BP-HRP Bundle | sc-531423 | 200 µg Ab; 10 µg BP | $354.00 | |||
QTRTD1 Antibody (E-4): m-IgGκ BP-HRP Bundle | sc-525109 | 200 µg Ab, 40 µg BP | $354.00 | |||
QTRTD1 Antibody (E-4): m-IgG1 BP-HRP Bundle | sc-544546 | 200 µg Ab; 20 µg BP | $354.00 | |||
QTRTD1 Antibody (E-4) AC | sc-515572 AC | 500 µg/ml, 25% agarose | $416.00 | |||
QTRTD1 Antibody (E-4) HRP | sc-515572 HRP | 200 µg/ml | $316.00 | |||
QTRTD1 Antibody (E-4) FITC | sc-515572 FITC | 200 µg/ml | $330.00 | |||
QTRTD1 Antibody (E-4) PE | sc-515572 PE | 200 µg/ml | $343.00 | |||
QTRTD1 Antibody (E-4) Alexa Fluor® 488 | sc-515572 AF488 | 200 µg/ml | $357.00 | |||
QTRTD1 Antibody (E-4) Alexa Fluor® 546 | sc-515572 AF546 | 200 µg/ml | $357.00 | |||
QTRTD1 Antibody (E-4) Alexa Fluor® 594 | sc-515572 AF594 | 200 µg/ml | $357.00 | |||
QTRTD1 Antibody (E-4) Alexa Fluor® 647 | sc-515572 AF647 | 200 µg/ml | $357.00 | |||
QTRTD1 Antibody (E-4) Alexa Fluor® 680 | sc-515572 AF680 | 200 µg/ml | $357.00 | |||
QTRTD1 Antibody (E-4) Alexa Fluor® 790 | sc-515572 AF790 | 200 µg/ml | $357.00 |