QAPRTase Antibody (ZN-17): sc-100809

QAPRTase Antibody (ZN-17) is a mouse monoclonal IgG1 kappa light chain antibody that detects the QAPRTase protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-QAPRTase antibody (ZN-17) is available as the non-conjugated format. Quinolinate phosphoribosyltransferase (QPRTase) plays a crucial role in the catabolism of quinolinate, an important intermediate in the tryptophan-nicotinamide adenine dinucleotide (NAD) pathway, which ultimately leads to the production of nicotinic acid, carbon dioxide, and pyrophosphate. The catabolism of quinolinate is particularly significant due to its neurotoxic properties; elevated levels of quinolinate have been associated with neurodegenerative symptoms in conditions such as meningitis and AIDS. QAPRTase features a unique seven-stranded alpha/beta-barrel domain, which is structurally similar to the eight-stranded alpha/beta-barrel enzymes but possesses a novel fold that distinguishes QAPRTase from other members of the phosphoribosyltransferase family. This distinctive structure consists of a combination of two domains: one resembling an alpha/beta barrel-like domain and the other an alpha/beta N-terminal domain, highlighting QPRTase′s evolutionary adaptation and functional significance in cellular metabolism.

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QAPRTase Antibody (ZN-17) References:

1. Quinolinate phosphoribosyltransferase: kinetic mechanism for a type II PRTase.  |  Cao, H., et al. 2002. Biochemistry. 41: 3520-8. PMID: 11876660
2. Crystallization and preliminary X-ray crystallographic analysis of quinolinate phosphoribosyltransferase of Helicobacter pylori.  |  Kim, MK., et al. 2003. Acta Crystallogr D Biol Crystallogr. 59: 1265-6. PMID: 12832780
3. Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 2.50 A resolution.  |  Schwarzenbacher, R., et al. 2004. Proteins. 55: 768-71. PMID: 15103640
4. Development of a multivariate statistical model to predict peroxisome proliferation in the rat, based on urinary 1H-NMR spectral patterns.  |  Connor, SC., et al. 2004. Biomarkers. 9: 364-85. PMID: 15764299
5. Tryptophan-NAD+ pathway metabolites as putative biomarkers and predictors of peroxisome proliferation.  |  Delaney, J., et al. 2005. Arch Toxicol. 79: 208-23. PMID: 15838709
6. Involvement of quinolinate phosphoribosyl transferase in promotion of potato growth by a Burkholderia strain.  |  Wang, K., et al. 2006. Appl Environ Microbiol. 72: 760-8. PMID: 16391116
7. Crystal structure of quinolinic acid phosphoribosyltransferase from Helicobacter pylori.  |  Kim, MK., et al. 2006. Proteins. 63: 252-5. PMID: 16419067
8. Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme.  |  Wang, T., et al. 2006. Nat Struct Mol Biol. 13: 661-2. PMID: 16783373
9. A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase.  |  Eads, JC., et al. 1997. Structure. 5: 47-58. PMID: 9016724

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-QAPRTase Antibody (ZN-17) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-QAPRTase Antibody (ZN-17) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

QAPRTase Antibody (ZN-17) Specifications

Alternate Product Name: QAPRTase

Product Clone Name: ZN-17

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 198-298

Epitope Target: QAPRTase

Epitope Species: human

Product Reactivity/Detection: QAPRTase

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for QAPRTase Antibody (ZN-17): N/A