QAPRTase Inhibitors
QAPRTase inhibitors represent a class of chemical compounds that exert their effects by targeting quinolinic acid phosphoribosyltransferase (QAPRTase), an enzyme involved in the de novo biosynthesis of nicotinamide adenine dinucleotide (NAD+). NAD+ is a crucial coenzyme involved in various cellular processes, including energy metabolism and DNA repair. QAPRTase, specifically, catalyzes the conversion of quinolinic acid to nicotinic acid mononucleotide, a key intermediate in the NAD+ biosynthetic pathway. Inhibiting QAPRTase activity disrupts this pathway, leading to downstream effects on cellular processes reliant on NAD+. As a consequence, QAPRTase inhibitors have garnered attention in the field of chemical biology as valuable tools for probing the intricacies of NAD+ metabolism and its impact on cellular function.
QAPRTase inhibitors exhibit diversity, with various scaffolds explored for their potential to interact with the enzyme's active site and impede its catalytic activity. The design and optimization of these inhibitors often involve a combination of computational modeling, structural biology studies, and synthetic chemistry approaches. Researchers aim to elucidate the structure-activity relationships that govern the efficacy of QAPRTase inhibitors, enabling the development of more potent and selective compounds. Beyond their utility as research tools, these inhibitors may also hold promise for more applications in the future, as a deeper understanding of their mechanisms of action emerges.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Competes with nicotinic acid, reducing its availability for NAD+ synthesis, which can indirectly decrease the activity of QAPRTase by reducing the need for its action in the NAD+ biosynthesis pathway. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Inhibits dihydrofolate reductase, leading to a reduction in folate metabolism and indirectly affecting purine synthesis, which can decrease the availability of PRPP, a substrate necessary for QAPRTase activity. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Metabolized to fluorouridine triphosphate, which can inhibit phosphoribosyl pyrophosphate amidotransferase, potentially reducing PRPP levels and indirectly affecting QAPRTase activity. | ||||||
6-Mercaptopurine | 50-44-2 | sc-361087 sc-361087A | 50 mg 100 mg | $71.00 $102.00 | ||
Purine analog that interferes with purine synthesis and metabolism, potentially reducing PRPP levels and indirectly affecting QAPRTase activity. | ||||||
Allopurinol | 315-30-0 | sc-207272 | 25 g | $128.00 | ||
Inhibitor of xanthine oxidase, leading to altered purine catabolism, which can indirectly affect PRPP availability and QAPRTase activity. | ||||||
(±)-Sulfinpyrazone | 57-96-5 | sc-202822 sc-202822A | 1 g 5 g | $39.00 $92.00 | 2 | |
Inhibits xanthine oxidase, which can indirectly affect PRPP availability and QAPRTase activity by altering purine catabolism. | ||||||
Azaserine | 115-02-6 | sc-29063 sc-29063A | 50 mg 250 mg | $306.00 $906.00 | 15 | |
Glutamine antagonist that inhibits amidophosphoribosyltransferase, potentially reducing the availability of PRPP and indirectly affecting QAPRTase activity. | ||||||
6-Diazo-5-oxo-L-norleucine | 157-03-9 | sc-227078 sc-227078A sc-227078B sc-227078C | 5 mg 25 mg 100 mg 250 mg | $82.00 $285.00 $908.00 $2152.00 | ||
Glutamine analog that inhibits glutamine-utilizing enzymes, which could lead to reduced PRPP availability and hence affect QAPRTase activity. | ||||||
Acivicin | 42228-92-2 | sc-200498B sc-200498C sc-200498 sc-200498D | 1 mg 5 mg 10 mg 25 mg | $102.00 $408.00 $642.00 $1275.00 | 10 | |
Inhibitor of glutamine-utilizing enzymes, potentially reducing the availability of PRPP and indirectly affecting QAPRTase activity. | ||||||
Phosphonoacetic acid | 4408-78-0 | sc-215712 sc-215712A | 10 g 50 g | $80.00 $321.00 | ||
Inhibits viral DNA polymerases and can also affect cellular enzymes involved in nucleotide synthesis, which could lead to reduced PRPP availability and indirectly affect QAPRTase activity. | ||||||