Pygopus 2 Antibody (B-4): sc-373994

Pygopus 2 Antibody (B-4) is a mouse monoclonal IgG1 antibody that detects Pygopus 2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Pygopus 2, also known as PYGO2, is a 406 amino acid protein that serves as the human homolog of the Drosophila pygopus protein and is primarily localized in the nucleus. PYGO2 plays a pivotal role in the Wnt signaling pathway by containing a PHD finger that interacts with the homology domain of the Wnt signaling protein Bcl-9. This interaction facilitates PYGO2′s association with the β-catenin/TCF complex, a critical component for the transcriptional activation of Wnt target genes. PYGO2′s proper functioning is vital for regulating signal transduction within the Wnt pathway; disruptions in this interaction may contribute to the development of B-cell malignancies. Additionally, PYGO2 expression is notably upregulated in breast cancer cells, indicating significant involvement in carcinogenesis and highlighting potential as a therapeutic target in cancer research. anti-Pygopus 2 antibody (B-4) is an invaluable tool for researchers investigating the complexities of Wnt signaling and its implications in various diseases.

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Pygopus 2 Antibody (B-4) References:

1. Requirement of Pygopus 2 in breast cancer.  |  Andrews, PG., et al. 2007. Int J Oncol. 30: 357-63. PMID: 17203217
2. pygopus 2 has a crucial, Wnt pathway-independent function in lens induction.  |  Song, N., et al. 2007. Development. 134: 1873-85. PMID: 17428831
3. Overexpression of Pygopus-2 is required for canonical Wnt activation in human lung cancer.  |  Zhou, SY., et al. 2014. Oncol Lett. 7: 233-238. PMID: 24348855
4. Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression.  |  Zhang, S., et al. 2015. Oncotarget. 6: 11074-86. PMID: 25871475
5. Logical design of an anti-cancer agent targeting the plant homeodomain in Pygopus2.  |  Ali, F., et al. 2016. Cancer Sci. 107: 1321-8. PMID: 27324116
6. Pygopus2 inhibits the efficacy of paclitaxel-induced apoptosis and induces multidrug resistance in human glioma cells.  |  Zhou, C., et al. 2017. Oncotarget. 8: 27915-27928. PMID: 28427190
7. PYGOPUS2 expression in prostatic adenocarcinoma is a potential risk stratification marker for PSA progression following radical prostatectomy.  |  Kao, KR., et al. 2018. J Clin Pathol. 71: 402-411. PMID: 28924059
8. Pygopus 2 promotes kidney cancer OS-RC-2 cells proliferation and invasion in vitro and in vivo.  |  Liu, R., et al. 2015. Asian J Urol. 2: 151-157. PMID: 29264135
9. Augmentation of Myc-Dependent Mitotic Gene Expression by the Pygopus2 Chromatin Effector.  |  Andrews, PGP., et al. 2018. Cell Rep. 23: 1516-1529. PMID: 29719262
10. A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer.  |  Saxena, M., et al. 2020. Cancer Res. 80: 3631-3648. PMID: 32586983

The preferred Pygopus 2 antibody is Pygopus 2 Antibody (B-12): sc-390506.