PTP sigma Antibody (SS-8): sc-100419

PTPσ Antibody (SS-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects PTPσ protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PTPσ antibody (SS-8) is available as the non-conjugated form. PTPσ is a receptor-type protein tyrosine phosphatase that plays a crucial role in various cellular processes, including cell signaling, development, and nerve repair. PTPσ is primarily located in the cell membrane, where PTPσ functions as a transmembrane protein, facilitating communication between the extracellular environment and intracellular signaling pathways. This localization allows PTPσ to interact with other membrane proteins and influence their phosphorylation status, thereby modulating cellular responses to external stimuli. PTPσ has been implicated in the regulation of insulin receptor signaling and may play a role in the repair mechanisms of adult nerves, highlighting PTPσ′s importance in both metabolic processes and neural regeneration. PTPσ′s structure includes an extracellular region, a single transmembrane segment, and two tandem intracytoplasmic catalytic domains, which are essential for enzymatic activity and interaction with other proteins. With four alternatively spliced transcript variants reported, PTPσ exhibits functional diversity that can impact various biological pathways, making anti-PTPσ antibody (SS-8) a valuable tool for researchers studying PTPσ′s role in health and disease.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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PTP sigma Antibody (SS-8) References:

1. Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes.  |  Fischer, EH., et al. 1991. Science. 253: 401-6. PMID: 1650499
2. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases.  |  Krueger, NX., et al. 1990. EMBO J. 9: 3241-52. PMID: 2170109
3. Mechanisms of PTPσ-Mediated Presynaptic Differentiation.  |  Bomkamp, C., et al. 2019. Front Synaptic Neurosci. 11: 17. PMID: 31191292
4. PTPσ inhibitors promote hematopoietic stem cell regeneration.  |  Zhang, Y., et al. 2019. Nat Commun. 10: 3667. PMID: 31413255
5. LRRTMs Organize Synapses through Differential Engagement of Neurexin and PTPσ.  |  Roppongi, RT., et al. 2020. Neuron. 106: 108-125.e12. PMID: 31995730
6. Inhibition of CSPG receptor PTPσ promotes migration of newly born neuroblasts, axonal sprouting, and recovery from stroke.  |  Luo, F., et al. 2022. Cell Rep. 40: 111137. PMID: 35905716
7. The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions.  |  Serra-Pagès, C., et al. 1995. EMBO J. 14: 2827-38. PMID: 7796809
8. Molecular characterization of the human transmembrane protein-tyrosine phosphatase delta. Evidence for tissue-specific expression of alternative human transmembrane protein-tyrosine phosphatase delta isoforms.  |  Pulido, R., et al. 1995. J Biol Chem. 270: 6722-8. PMID: 7896816
9. Cloning and expression of two structurally distinct receptor-linked protein-tyrosine phosphatases generated by RNA processing from a single gene.  |  Pan, MG., et al. 1993. J Biol Chem. 268: 19284-91. PMID: 8396131
10. The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1.  |  Pulido, R., et al. 1995. Proc Natl Acad Sci U S A. 92: 11686-90. PMID: 8524829
11. Protein tyrosine phosphatases in signal transduction.  |  Neel, BG. and Tonks, NK. 1997. Curr Opin Cell Biol. 9: 193-204. PMID: 9069265
12. The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma.  |  Wallace, MJ., et al. 1998. Mol Cell Biol. 18: 2608-16. PMID: 9566880

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PTPσ Antibody (SS-8) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-PTPσ Antibody (SS-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PTPσ Antibody (SS-8) Specifications

Alternate Product Name: PTPσ

Product Clone Name: SS-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-129

Epitope Target: PTPσ

Epitope Species: human

Product Reactivity/Detection: PTPσ

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for PTPσ Antibody (SS-8): N/A