PTP IA-2 Antibody (AFT38): sc-135672
- PTP IA-2 Antibody (AFT38) is a mouse monoclonal IgG1 provided at 100 µl
- raised against recombinant PTP IA-2 of human origin
- recommended for detection of PTP IA-2 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PTP IA-2 Antibody (AFT38). This work is in progress.
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SEE ALSO...
PTP IA-2 Antibody (AFT38) is a mouse monoclonal IgG1 antibody that detects PTP IA-2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). PTP IA-2, also known as PTPRN, IA2, ICA512, or RPTPN, is a receptor-type protein tyrosine phosphatase that plays a crucial role in the regulation of secretory granule exocytosis, particularly in neuroendocrine cells, including pancreatic islet cells. PTP IA-2 is characterized by a transmembrane region, an intracellular phosphatase domain, and an extracellular N-terminus, which are essential for cellular signaling pathways. The localization of PTP IA-2 to secretory granules directly influences the secretion of hormones, such as insulin, thereby impacting glucose metabolism and homeostasis. PTP IA-2 is recognized as an autoantigen in insulin-dependent diabetes mellitus (IDDM), and autoantibodies against PTP IA-2 serve as a valuable diagnostic marker for the disease. Anti-PTP IA-2 antibody (AFT38) enables researchers to gain insights into the molecular mechanisms underlying diabetes and the role of PTP IA-2 in neuroendocrine function.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTP IA-2 Antibody (AFT38) | sc-135672 | 100 µl | $316.00 |