PTH Antibody (77/78): sc-57416
- PTH Antibody (77/78) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 1-37 of PTH of human origin
- recommended for detection of PTH peptides (aa 24-37; 16-24; 1-84; 7-84; 1-34; 1-37; 1-38) of human origin by IF and IHC(P); non cross-reactive with synthetic Parathyroid hormone peptide (aa 1-3; 1-10)
- See PTH/PTHrP-R (3D1.1): sc-12722 for PTH antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PTH Antibody (77/78). This work is in progress.
QUICK LINKS
PTH Antibody (77/78) is a mouse monoclonal IgG1 antibody that detects parathyroid hormone (PTH) in human samples through immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). PTH is a crucial 84 amino acid peptide that plays a vital role in regulating calcium metabolism, primarily by increasing blood calcium levels through various mechanisms, including stimulating bone formation and enhancing renal tubular reabsorption of calcium. The first 34 amino acids at the amino terminus of the PTH molecule are essential for biological activity, making them a key focus for understanding function. The gene encoding PTH is located on human chromosome 11p15.3-p15.1, and regulation is influenced by vitamin D and steroid hormones, which are critical for maintaining calcium homeostasis in the body. PTH interacts with specific PTH/PTH-rP receptors, activating signaling pathways that lead to increased bone mass and strength, highlighting importance in both physiological and pathological processes. Additionally, parathyroid hormone-related protein (PTH-rP), which shares structural similarities with PTH, is synthesized by various cell types and plays a significant role in endochondral bone development and epithelial-mesenchymal interactions, further underscoring PTH relevance in both normal physiology and disease states.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTH Antibody (77/78) | sc-57416 | 50 µg/0.5 ml | $316.00 |