PTH Antibody (77/78): sc-57416

PTH Antibody (77/78) is a mouse monoclonal IgG1 antibody that detects parathyroid hormone (PTH) in human samples through immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). PTH is a crucial 84 amino acid peptide that plays a vital role in regulating calcium metabolism, primarily by increasing blood calcium levels through various mechanisms, including stimulating bone formation and enhancing renal tubular reabsorption of calcium. The first 34 amino acids at the amino terminus of the PTH molecule are essential for biological activity, making them a key focus for understanding function. The gene encoding PTH is located on human chromosome 11p15.3-p15.1, and regulation is influenced by vitamin D and steroid hormones, which are critical for maintaining calcium homeostasis in the body. PTH interacts with specific PTH/PTH-rP receptors, activating signaling pathways that lead to increased bone mass and strength, highlighting importance in both physiological and pathological processes. Additionally, parathyroid hormone-related protein (PTH-rP), which shares structural similarities with PTH, is synthesized by various cell types and plays a significant role in endochondral bone development and epithelial-mesenchymal interactions, further underscoring PTH relevance in both normal physiology and disease states.

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Contains Mercury: This product contains thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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PTH Antibody (77/78) References:

1. Parathyroid hormone (PTH), PTH-derived peptides, and new PTH assays in renal osteodystrophy.  |  Goodman, WG., et al. 2003. Kidney Int. 63: 1-11. PMID: 12472763
2. New PTH assays and renal osteodystrophy.  |  Salusky, IB. and Jüppner, H. 2004. Pediatr Nephrol. 19: 709-13. PMID: 15173936
3. Influence of parathyroid mass on the regulation of PTH secretion.  |  Lewin, E. and Olgaard, K. 2006. Kidney Int Suppl. S16-21. PMID: 16810305
4. Evidence for the role of perioperative PTH measurement after total thyroidectomy as a predictor of hypocalcemia.  |  Grodski, S. and Serpell, J. 2008. World J Surg. 32: 1367-73. PMID: 18340480
5. PTH Reloaded: A New Evolutionary Perspective.  |  Suarez-Bregua, P., et al. 2017. Front Physiol. 8: 776. PMID: 29062283
6. Novel PTH Gene Mutations Causing Isolated Hypoparathyroidism.  |  Hawkes, CP., et al. 2022. J Clin Endocrinol Metab. 107: e2449-e2458. PMID: 35165722
7. Parathyroid Hormone (PTH)-Related Peptides Family: An Intriguing Role in the Central Nervous System.  |  Dettori, C., et al. 2023. J Pers Med. 13: PMID: 37240884
8. Big data-based parathyroid hormone (PTH) values emphasize need for age correction.  |  Cavalcante, LBCP., et al. 2023. J Endocrinol Invest. 46: 2525-2533. PMID: 37286864
9. Inverse correlation of intact PTH, oxidized PTH as well as non-oxidized PTH with 25-hydroxyvitamin D3 in kidney transplant recipients.  |  Zuo, J., et al. 2023. Front Endocrinol (Lausanne). 14: 1178166. PMID: 37324252
10. Interactions between PTH and adiposity: appetizing possibilities.  |  Tay Donovan, YK. and Bilezikian, JP. 2024. J Bone Miner Res. 39: 536-543. PMID: 38637302

The preferred PTH antibody is PTH Antibody (H-7): sc-398856.