PTH Inhibitors
Parathyroid hormone (PTH) inhibitors represent a class of chemical compounds that primarily target the regulation of calcium homeostasis within the human body. These inhibitors are designed to interact with and modulate the activity of parathyroid hormone, a critical hormone secreted by the parathyroid glands located in the neck. The primary function of PTH is to maintain the balance of calcium and phosphate in the bloodstream and to regulate calcium levels in bone tissue. PTH inhibitors, as the name suggests, interfere with the action of PTH, thereby influencing the dynamics of calcium and phosphate metabolism in the body.
Within the category of PTH inhibitors, various chemical structures and mechanisms of action can be found. Some PTH inhibitors work by directly binding to the PTH receptor, while others may interfere with the production or secretion of PTH. Calcium-sensing receptors play a crucial role in the regulation of PTH secretion, and certain inhibitors may also target these receptors to influence PTH levels indirectly. By manipulating the PTH pathway, these inhibitors can help regulate calcium levels in cases of hypercalcemia or hypocalcemia, conditions characterized by excess or deficient calcium in the bloodstream, respectively.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is known to influence calcium signaling pathways, which may indirectly affect PTH expression through alteration of calcium sensing receptor (CaSR) activity. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $46.00 $69.00 $163.00 $245.00 $418.00 | 3 | |
Magnesium acts as a cofactor for many enzymatic reactions, including those involved in hormone secretion, and can influence PTH expression by altering calcium balance. | ||||||
Strontium Ranelate | 135459-87-9 | sc-208403 | 10 mg | $320.00 | ||
Strontium has been shown to affect calcium sensing in the parathyroid glands, potentially leading to changes in PTH secretion. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $40.00 $46.00 $100.00 | 26 | |
Chronic exposure to fluoride can alter mineral metabolism and is associated with changes in parathyroid hormone levels. | ||||||
Aluminum hydroxide | 21645-51-2 | sc-214529 sc-214529A | 100 g 500 g | $39.00 $55.00 | 3 | |
Aluminium exposure is linked to bone metabolism disturbances, which may include the downregulation of PTH secretion. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Cadmium can affect various endocrine functions and may alter calcium signaling, thereby influencing PTH expression. | ||||||
Lead(II) Acetate | 301-04-2 | sc-507473 | 5 g | $85.00 | ||
Lead exposure is known to disrupt calcium dynamics and can interfere with the regulation of parathyroid hormone expression. | ||||||
Alendronate acid | 66376-36-1 | sc-337520 | 5 g | $135.00 | 2 | |
This compound can affect bone metabolism and indirectly alter PTH secretion due to its effects on bone resorption. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
As an inhibitor of steroid biosynthesis, ketoconazole can indirectly affect the regulation of various hormones, potentially including PTH. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
This glucocorticoid can affect calcium metabolism and hence may modulate PTH secretion. | ||||||