PTH Antibody (H-7): sc-398856
- PTH Antibody (H-7) is a mouse monoclonal IgG1 κ PTH antibody provided at 200 µg/ml
- raised against amino acids 1-115 representing full length PTH of human origin
- PTH Antibody (H-7) is recommended for detection of precursor and mature PTH of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-PTH Antibody (H-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PTH Antibody (H-7) for WB and IHC(P) applications. These reagents are now offered in bundles with PTH Antibody (H-7) (see ordering information below).
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PTH Antibody (H-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects PTH protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-PTH antibody (H-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Parathyroid hormone (PTH), also known as parathyrin, is an 84 amino acid single-chain peptide that plays a crucial role in regulating calcium metabolism by increasing blood calcium levels through several mechanisms, including stimulating bone formation and enhancing renal tubular reabsorption of calcium. The first 34 amino acids at the amino terminus of the PTH molecule are essential for biological activity, making this region a key target for therapeutic interventions in calcium-related disorders. The gene encoding PTH is located on human chromosome 11p15.3-p15.1, and PTH is closely related to parathyroid hormone-related protein (PTH-rP), which is synthesized by various cell types and regulates endochondral bone development. Both PTH and PTH-rP are influenced by vitamin D and steroid hormones, and these proteins exert their effects by binding to specific PTH/PTH-rP receptors, activating signaling pathways that lead to increased calcium levels in the bloodstream.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PTH Antibody (H-7) References:
- Regional mapping of the parathyroid hormone gene (PTH) by cytogenetic and molecular studies. | Tonoki, H., et al. 1991. Cytogenet Cell Genet. 56: 103-4. PMID: 1672845
- Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy. | Mangin, M., et al. 1988. Proc Natl Acad Sci U S A. 85: 597-601. PMID: 2829195
- A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. | Suva, LJ., et al. 1987. Science. 237: 893-6. PMID: 3616618
- Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro. | Horiuchi, N., et al. 1987. Science. 238: 1566-8. PMID: 3685994
- Human parathyroid hormone: amino-acid sequence of the amino-terminal residues 1-34. | Brewer, HB., et al. 1972. Proc Natl Acad Sci U S A. 69: 3585-8. PMID: 4509319
- Isolation of human parathyroid hormone. | O'Riordan, JL., et al. 1971. Endocrinology. 89: 234-9. PMID: 5092521
- Parathyroid hormone: regulation of synthesis and secretion. | Watson, PH. and Hanley, DA. 1993. Clin Invest Med. 16: 58-77. PMID: 8467581
- PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. | Lanske, B., et al. 1996. Science. 273: 663-6. PMID: 8662561
- Parathyroid hormone-related protein and hypercalcemia. | Rankin, W., et al. 1997. Cancer. 80: 1564-71. PMID: 9362423
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTH Antibody (H-7) | sc-398856 | 200 µg/ml | $322.00 | |||
PTH Antibody (H-7): m-IgG Fc BP-HRP Bundle | sc-527826 | 200 µg Ab; 10 µg BP | $361.00 | |||
PTH Antibody (H-7): m-IgG1 BP-HRP Bundle | sc-533199 | 200 µg Ab; 20 µg BP | $361.00 | |||
PTH Antibody (H-7) AC | sc-398856 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PTH Antibody (H-7) HRP | sc-398856 HRP | 200 µg/ml | $322.00 | |||
PTH Antibody (H-7) FITC | sc-398856 FITC | 200 µg/ml | $336.00 | |||
PTH Antibody (H-7) PE | sc-398856 PE | 200 µg/ml | $349.00 | |||
PTH Antibody (H-7) Alexa Fluor® 488 | sc-398856 AF488 | 200 µg/ml | $364.00 | |||
PTH Antibody (H-7) Alexa Fluor® 546 | sc-398856 AF546 | 200 µg/ml | $364.00 | |||
PTH Antibody (H-7) Alexa Fluor® 594 | sc-398856 AF594 | 200 µg/ml | $364.00 | |||
PTH Antibody (H-7) Alexa Fluor® 647 | sc-398856 AF647 | 200 µg/ml | $364.00 | |||
PTH Antibody (H-7) Alexa Fluor® 680 | sc-398856 AF680 | 200 µg/ml | $364.00 | |||
PTH Antibody (H-7) Alexa Fluor® 790 | sc-398856 AF790 | 200 µg/ml | $364.00 |