PTH Antibody (6D7): sc-69931
- PTH Antibody (6D7) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against amino acids 39-68 of PTH of human origin
- recommended for detection of PTH of human origin by WB, IP and ELISA
- See PTH/PTHrP-R (3D1.1): sc-12722 for PTH antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PTH Antibody (6D7). This work is in progress.
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PTH Antibody (6D7) is a mouse monoclonal IgG1 antibody that detects parathyroid hormone (PTH) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). PTH is a crucial 84 amino acid peptide that plays a vital role in regulating calcium metabolism, primarily by increasing blood calcium levels through various mechanisms, including stimulating bone formation to enhance bone mass and strength. The first 34 amino acids at the amino terminus of the PTH molecule are essential for biological activity, highlighting the importance of this region in function. The gene encoding PTH is located on human chromosome 11p15.3-p15.1, and regulation is influenced by vitamin D and steroid hormones. Notably, PTH interacts with specific PTH/PTH-rP receptors, activating signaling pathways that lead to increased calcium levels in the bloodstream. Additionally, parathyroid hormone-related protein (PTH-rP), which is structurally similar to PTH, is synthesized by various cell types and plays a significant role in endochondral bone development and epithelial-mesenchymal interactions, further underscoring the importance of PTH in both physiological and pathological processes. Anti-PTH antibody (6D7) is an invaluable tool for researchers studying calcium homeostasis and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PTH Antibody (6D7) References:
- PTH and PTH-related peptide enhance steroid secretion from human adrenocortical cells. | Mazzocchi, G., et al. 2001. Am J Physiol Endocrinol Metab. 280: E209-13. PMID: 11158922
- Origin of parathyroid hormone (PTH) fragments detected by intact-PTH assays. | Nguyen-Yamamoto, L., et al. 2002. Eur J Endocrinol. 147: 123-31. PMID: 12088929
- [Significance of a new PTH assay (the comparison between whole-PTH and intact-PTH assay)]. | Ito, N. and Fukumoto, S. 2004. Clin Calcium. 14: 55-6. PMID: 15577110
- PTH receptors and apoptosis in osteocytes. | Bringhurst, FR. 2002. J Musculoskelet Neuronal Interact. 2: 245-51. PMID: 15758445
- Switching between parathormone (PTH) assays: the impact on the diagnosis of renal osteodystrophy. | Bekő, G., et al. 2013. Clin Chem Lab Med. 51: 1251-6. PMID: 23241601
- Comparison of Intact PTH and Bio-Intact PTH Assays Among Non-Dialysis Dependent Chronic Kidney Disease Patients. | Einbinder, Y., et al. 2017. Ann Lab Med. 37: 381-387. PMID: 28643486
- Oxidation of PTH: in vivo feature or effect of preanalytical conditions? | Ursem, SR., et al. 2018. Clin Chem Lab Med. 56: 249-255. PMID: 28809747
- Comparison between Second- and Third-Generation PTH Assays during Minimally Invasive Parathyroidectomy (MIP). | Gannagé-Yared, MH., et al. 2020. Int J Endocrinol. 2020: 5230985. PMID: 32256573
- Non-oxidized parathyroid hormone (PTH) measured by current method is not superior to total PTH in assessing bone turnover in chronic kidney disease. | Ursem, SR., et al. 2021. Kidney Int. 99: 1173-1178. PMID: 33422551
- Maintenance of increased bone mass after PTH withdrawal by sequential medicarpin treatment via augmentation of cAMP-PKA pathway. | Sharma, K., et al. 2022. J Cell Biochem. 123: 1762-1779. PMID: 35959633
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTH Antibody (6D7) | sc-69931 | 100 µg/ml | $322.00 |