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PTH Antibody (6D7) is a mouse monoclonal IgG1 antibody that detects parathyroid hormone (PTH) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). PTH is a crucial 84 amino acid peptide that plays a vital role in regulating calcium metabolism, primarily by increasing blood calcium levels through various mechanisms, including stimulating bone formation to enhance bone mass and strength. The first 34 amino acids at the amino terminus of the PTH molecule are essential for biological activity, highlighting the importance of this region in function. The gene encoding PTH is located on human chromosome 11p15.3-p15.1, and regulation is influenced by vitamin D and steroid hormones. Notably, PTH interacts with specific PTH/PTH-rP receptors, activating signaling pathways that lead to increased calcium levels in the bloodstream. Additionally, parathyroid hormone-related protein (PTH-rP), which is structurally similar to PTH, is synthesized by various cell types and plays a significant role in endochondral bone development and epithelial-mesenchymal interactions, further underscoring the importance of PTH in both physiological and pathological processes. Anti-PTH antibody (6D7) is an invaluable tool for researchers studying calcium homeostasis and related disorders.
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTH Antibody (6D7) | sc-69931 | 100 µg/ml | $316.00 |