PTEN Antibody (10P01): sc-73420

PTEN Antibody (10P01) is a mouse monoclonal IgG2a kappa light chain antibody engineered to recognize the full-length PTEN protein, also known as phosphatase and tensin homolog, MMAC1, or TEP1. anti-PTEN antibody (10P01) is specifically validated for immunoprecipitation (IP) applications with human PTEN, enabling precise detection and analysis of this crucial tumor suppressor protein. PTEN plays a vital role in regulating cellular processes by dephosphorylating phosphatidylinositol (3,4,5)-trisphosphate, thereby antagonizing the PI3K/AKT signaling pathway, which is essential for controlling cell growth, proliferation, and survival. The proper function of PTEN is further regulated through various post-translational modifications, including phosphorylation and ubiquitination, which influence stability, localization, and enzymatic activity. Dysregulation or mutation of PTEN, often observed in numerous cancers such as glioblastomas, breast, kidney, and prostate cancers, underscores its importance in maintaining cellular homeostasis and preventing tumorigenesis. Additionally, PTEN is associated with Cowden disease, an autosomal dominant condition that predisposes individuals to multiple cancer types. By targeting the full-length PTEN protein, PTEN monoclonal antibody (10P01) facilitates the investigation of PTEN′s regulatory mechanisms and interactions within cellular pathways, providing researchers with a powerful tool to explore the molecular underpinnings of cancer development and progression. PTEN (10P01) antibody is recommended for researchers aiming to elucidate the complex roles of PTEN in cancer biology and to develop targeted therapeutic strategies.

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PTEN Antibody (10P01) References:

1. PTEN level in tumor suppression: how much is too little?  |  Carracedo, A., et al. 2011. Cancer Res. 71: 629-33. PMID: 21266353
2. PTEN function: the long and the short of it.  |  Hopkins, BD., et al. 2014. Trends Biochem Sci. 39: 183-90. PMID: 24656806
3. Posttranslational regulation of phosphatase and tensin homolog (PTEN) and its functional impact on cancer behaviors.  |  Xu, W., et al. 2014. Drug Des Devel Ther. 8: 1745-51. PMID: 25336918
4. PTEN ceRNA networks in human cancer.  |  Poliseno, L. and Pandolfi, PP. 2015. Methods. 77-78: 41-50. PMID: 25644446
5. PTEN: Multiple Functions in Human Malignant Tumors.  |  Milella, M., et al. 2015. Front Oncol. 5: 24. PMID: 25763354
6. Precise Immunodetection of PTEN Protein in Human Neoplasia.  |  Pulido, R., et al. 2019. Cold Spring Harb Perspect Med. 9: PMID: 31501265
7. Recent advances in PTEN signalling axes in cancer.  |  Chow, JT. and Salmena, L. 2020. Fac Rev. 9: 31. PMID: 33659963
8. Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor.  |  He, T., et al. 2021. Front Physiol. 12: 684529. PMID: 34140896
9. Non-canonical function of nuclear PTEN and its implication on tumorigenesis.  |  Misra, S., et al. 2021. DNA Repair (Amst). 107: 103197. PMID: 34359000
10. Regulation of the tumor suppressor PTEN in triple-negative breast cancer.  |  Chai, C., et al. 2022. Cancer Lett. 527: 41-48. PMID: 34902523

The preferred PTEN antibody is PTEN Antibody (A2B1): sc-7974.