PTEN Antibody (10P01): sc-73420

PTEN Antibody (10P01) is a mouse monoclonal IgG2a kappa light chain antibody engineered to recognize the full-length PTEN protein, also known as phosphatase and tensin homolog, MMAC1, or TEP1. anti-PTEN antibody (10P01) is specifically validated for immunoprecipitation (IP) applications with human PTEN, enabling precise detection and analysis of this crucial tumor suppressor protein. PTEN plays a vital role in regulating cellular processes by dephosphorylating phosphatidylinositol (3,4,5)-trisphosphate, thereby antagonizing the PI3K/AKT signaling pathway, which is essential for controlling cell growth, proliferation, and survival. The proper function of PTEN is further regulated through various post-translational modifications, including phosphorylation and ubiquitination, which influence stability, localization, and enzymatic activity. Dysregulation or mutation of PTEN, often observed in numerous cancers such as glioblastomas, breast, kidney, and prostate cancers, underscores its importance in maintaining cellular homeostasis and preventing tumorigenesis. Additionally, PTEN is associated with Cowden disease, an autosomal dominant condition that predisposes individuals to multiple cancer types. By targeting the full-length PTEN protein, PTEN monoclonal antibody (10P01) facilitates the investigation of PTEN′s regulatory mechanisms and interactions within cellular pathways, providing researchers with a powerful tool to explore the molecular underpinnings of cancer development and progression. PTEN (10P01) antibody is recommended for researchers aiming to elucidate the complex roles of PTEN in cancer biology and to develop targeted therapeutic strategies.

The preferred PTEN antibody is PTEN Antibody (A2B1): sc-7974.