PSPH Antibody (H-11): sc-365183

PSPH Antibody (H-11) is a mouse monoclonal IgG2b antibody that detects phosphoserine phosphatase (PSPH) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PSPH is a crucial enzyme composed of 225 amino acids that plays a vital role in the biosynthesis of serine, catalyzing the final and irreversible step of converting O-phosphoserine into serine, a process that is essential for protein and nucleotide synthesis as well as cell signaling. The importance of serine extends beyond metabolic functions; serine is also involved in various cellular processes, including the regulation of cell growth and differentiation. Notably, PSPH is highly expressed in periventricular neural progenitors in the embryonic brain, suggesting a significant role in neural stem cell proliferation and development. Deficiencies in PSPH have been linked to serious health issues, including pre- and postnatal growth retardation and moderate psychomotor retardation in humans, highlighting PSPH′s critical function in early development and overall cellular health. Anti-PSPH antibody (H-11) serves as an invaluable tool for researchers studying the intricate roles of serine and its biosynthetic pathways.

The preferred PSPH antibody is PSPH Antibody (H-10): sc-271421.