PSPH Antibody (H-10): sc-271421

PSPH Antibody (H-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects PSPH protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PSPH (H-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PSPH protein, also known as phosphoserine phosphatase, plays a crucial role in the biosynthesis of serine, an essential amino acid involved in protein and nucleotide synthesis, as well as cell signaling pathways. This 225 amino acid enzyme is Mg(2+)-dependent and catalyzes the final and irreversible step in converting carbohydrates to serine through the hydrolysis of O-phosphoserine. Notably, PSPH is highly expressed in the embryonic brain, particularly in periventricular neural progenitors, where PSPH is believed to contribute to neural stem cell proliferation. A deficiency in PSPH can lead to significant developmental issues, including pre- and postnatal growth retardation and moderate psychomotor retardation in humans.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

PSPH Antibody (H-10) References:

1. Mechanistic studies of phosphoserine phosphatase, an enzyme related to P-type ATPases.  |  Collet, JF., et al. 1999. J Biol Chem. 274: 33985-90. PMID: 10567362
2. How calcium inhibits the magnesium-dependent enzyme human phosphoserine phosphatase.  |  Peeraer, Y., et al. 2004. Eur J Biochem. 271: 3421-7. PMID: 15291819
3. A Porphyromonas gingivalis haloacid dehalogenase family phosphatase interacts with human phosphoproteins and is important for invasion.  |  Tribble, GD., et al. 2006. Proc Natl Acad Sci U S A. 103: 11027-32. PMID: 16832066
4. DNA microarray reveals novel genes induced by mechanical forces in fetal lung type II epithelial cells.  |  Wang, Y., et al. 2006. Pediatr Res. 60: 118-24. PMID: 16864689
5. Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation.  |  Nakano, I., et al. 2007. Stem Cells. 25: 1975-84. PMID: 17495110
6. Assignment of the human phosphoserine phosphatase gene (PSP) to the pter leads to q22 region of chromosome 7.  |  Koch, GA., et al. 1983. Cytogenet Cell Genet. 35: 67-9. PMID: 6297854
7. The human phosphoserine phosphatase gene (PSP) is mapped to chromosome 7 by somatic cell genetic analysis.  |  Sparkes, RS., et al. 1983. Cytogenet Cell Genet. 35: 70-1. PMID: 6297855
8. Human L-3-phosphoserine phosphatase: sequence, expression and evidence for a phosphoenzyme intermediate.  |  Collet, JF., et al. 1997. FEBS Lett. 408: 281-4. PMID: 9188776
9. Phosphoserine phosphatase deficiency in a patient with Williams syndrome.  |  Jaeken, J., et al. 1997. J Med Genet. 34: 594-6. PMID: 9222972

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PSPH Antibody (H-10) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-PSPH Antibody (H-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PSPH Antibody (H-10) Specifications

Alternate Product Name: PSPH

Product Clone Name: H-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-225

Epitope Target: PSPH

Epitope Species: human

Product Reactivity/Detection: PSPH

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for PSPH Antibody (H-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin