Psoriasin Antibody (H-8): sc-377084

Psoriasin Antibody (H-8) is a mouse monoclonal IgG2b antibody that detects Psoriasin in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Psoriasin, also known as PSOR1 or S-100A7, is a 101 amino acid protein belonging to the S-100 family of calcium-binding proteins, which plays a crucial role in regulating numerous cellular processes such as cell cycle, progression, and differentiation. Psoriasin is primarily located in the cytoplasm and is secreted via a non-classical secretory pathway, highlighting its importance in cellular signaling and communication. Notably, Psoriasin is highly expressed in psoriatic epidermis and has been implicated in bladder squamous cell carcinoma and breast cancer, suggesting potential involvement in carcinogenesis. The gene encoding Psoriasin, along with the related S100A15 gene, evolved from a common ancestral gene in mice, with human S100A15 gene encoding a calcium-binding protein sharing 95% sequence identity with Psoriasin. Psoriasin′s unique structural features, including two EF-hand domains, underscore its significance in calcium signaling and potential as a biomarker for various diseases.

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Psoriasin Antibody (H-8) References:

1. Psoriasin interacts with Jab1 and influences breast cancer progression.  |  Emberley, ED., et al. 2003. Cancer Res. 63: 1954-61. PMID: 12702588
2. Psoriasin (S100A7) increases the expression of ROS and VEGF and acts through RAGE to promote endothelial cell proliferation.  |  Shubbar, E., et al. 2012. Breast Cancer Res Treat. 134: 71-80. PMID: 22189627
3. Psoriasin (S100A7) is a positive regulator of survival and invasion of prostate cancer cells.  |  Ye, L., et al. 2013. Urol Oncol. 31: 1576-83. PMID: 22694938
4. Reduced expression of psoriasin in human airway cystic fibrosis epithelia.  |  Li, T. and Cowley, EA. 2012. Respir Physiol Neurobiol. 183: 177-85. PMID: 22772316
5. Expression and function of psoriasin (S100A7) and koebnerisin (S100A15) in the brain.  |  Jansen, S., et al. 2013. Infect Immun. 81: 1788-97. PMID: 23478321
6. Th2 cytokines differentially regulate psoriasin expression in human nasal epithelia.  |  Min, HJ., et al. 2014. Am J Rhinol Allergy. 28: 449-53. PMID: 25514480
7. Overexpression of Psoriasin (S100A7) Contributes to Dysregulated Differentiation in Psoriasis.  |  Ekman, AK., et al. 2017. Acta Derm Venereol. 97: 441-448. PMID: 27958610
8. A potential contribution of psoriasin to vascular and epithelial abnormalities and inflammation in systemic sclerosis.  |  Takahashi, T., et al. 2018. J Eur Acad Dermatol Venereol. 32: 291-297. PMID: 28681537
9. Increased expression of Psoriasin is correlated with poor prognosis of bladder transitional cell carcinoma by promoting invasion and proliferation.  |  Liu, J., et al. 2020. Oncol Rep. 43: 562-570. PMID: 31894335
10. The role of High-mobility group box-1 and Psoriasin in multiple myeloma: Analysis of a population affected by monoclonal gammopathies and review of the literature.  |  Casciaro, M., et al. 2023. Pathol Res Pract. 247: 154562. PMID: 37216746

The preferred Psoriasin antibody is Psoriasin Antibody (H-6): sc-166869.