PSMD8 Antibody (H-11): sc-514053
- PSMD8 Antibody (H-11) is a mouse monoclonal IgG2b κ PSMD8 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 129-154 within an internal region of PSMD8 of human origin
- PSMD8 Antibody (H-11) is recommended for detection of PSMD8 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PSMD8 Antibody (H-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of PSMD8 (H-11): sc-514053.
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PSMD8 Antibody (H-11) for WB applications. These reagents are now offered in bundles with PSMD8 Antibody (H-11) (see ordering information below).
PSMD8 Antibody (H-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects PSMD8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PSMD8 (H-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PSMD8 protein, also known as HIP6, HYPF, Nin1p, Rpn12, S14, or p31, is a crucial regulatory component of the 26S proteasome, which plays a vital role in maintaining cellular homeostasis by selectively degrading ubiquitinated proteins. This selective degradation is essential for various cellular processes, including the regulation of the cell cycle, modulation of signal transduction pathways, and the removal of damaged or misfolded proteins. The 26S proteasome is composed of a 20S core particle that houses the proteolytic activity and two 19S regulatory particles that facilitate the recognition and unfolding of ubiquitinated substrates. PSMD8, consisting of 257 amino acids, is integral to the activation of CDC28 kinase and is encoded by a gene located on human chromosome 19q13.2. The ability of PSMD8 to interact with other proteins within the proteasome complex underscores its importance in proteostasis and cellular function, making anti-PSMD8 antibody (H-11) a valuable tool for researchers studying protein degradation pathways and their implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PSMD8 Antibody (H-11) References:
- Mass spectrometric analysis of expression of ATPase subunits encoded by duplicated genes in the 19S regulatory particle of rice 26S proteasome. | Shibahara, T., et al. 2004. Arch Biochem Biophys. 421: 34-41. PMID: 14678782
- Construction of a high-resolution comparative gene map between swine chromosome region 6q11-->q21 and human chromosome 19 q-arm by RH mapping of 51 genes. | Bosak, N., et al. 2003. Cytogenet Genome Res. 102: 109-15. PMID: 14970688
- Effects of tumor necrosis factor-alpha on the 26S proteasome and 19S regulator in skeletal muscle of severely scalded mice. | Tan, Y., et al. 2006. J Burn Care Res. 27: 226-33. PMID: 16566573
- Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. | Wang, X., et al. 2007. Biochemistry. 46: 3553-65. PMID: 17323924
- On a basic 31 kDa muscle membrane protein in cattle and pig, presumably equivalent to the class II antigen associated p31 molecule. | Thinnes, FP., et al. 1984. Anim Blood Groups Biochem Genet. 15: 181-9. PMID: 6517391
- Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae. | Kominami, K., et al. 1995. EMBO J. 14: 3105-15. PMID: 7621825
- Expression of early lung cancer detection marker p31 in neoplastic and non-neoplastic respiratory epithelium. | Zhou, J., et al. 1996. Lung Cancer. 14: 85-97. PMID: 8696723
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSMD8 Antibody (H-11) | sc-514053 | 200 µg/ml | $316.00 | |||
PSMD8 Antibody (H-11): m-IgGκ BP-HRP Bundle | sc-524589 | 200 µg Ab, 40 µg BP | $354.00 | |||
PSMD8 Antibody (H-11): m-IgG2b BP-HRP Bundle | sc-549169 | 200 µg Ab; 10 µg BP | $354.00 | |||
PSMD8 Antibody (H-11) AC | sc-514053 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PSMD8 Antibody (H-11) HRP | sc-514053 HRP | 200 µg/ml | $316.00 | |||
PSMD8 Antibody (H-11) FITC | sc-514053 FITC | 200 µg/ml | $330.00 | |||
PSMD8 Antibody (H-11) PE | sc-514053 PE | 200 µg/ml | $343.00 | |||
PSMD8 Antibody (H-11) Alexa Fluor® 488 | sc-514053 AF488 | 200 µg/ml | $357.00 | |||
PSMD8 Antibody (H-11) Alexa Fluor® 546 | sc-514053 AF546 | 200 µg/ml | $357.00 | |||
PSMD8 Antibody (H-11) Alexa Fluor® 594 | sc-514053 AF594 | 200 µg/ml | $357.00 | |||
PSMD8 Antibody (H-11) Alexa Fluor® 647 | sc-514053 AF647 | 200 µg/ml | $357.00 | |||
PSMD8 Antibody (H-11) Alexa Fluor® 680 | sc-514053 AF680 | 200 µg/ml | $357.00 | |||
PSMD8 Antibody (H-11) Alexa Fluor® 790 | sc-514053 AF790 | 200 µg/ml | $357.00 | |||
PSMD8 (H-11) Neutralizing Peptide | sc-514053 P | 100 µg/0.5 ml | $68.00 |