PSK2 Antibody (22): sc-136094

PSK2 Antibody (22) is a mouse monoclonal IgG1 kappa light chain antibody that detects PSK2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-PSK2 antibody (22) is available as a non-conjugated format. PSK2, also known as Prostate-derived STE20-like kinase 2, plays a crucial role in cellular signaling pathways, particularly in regulating the p38 MAP kinase pathway. This pathway is vital for various cellular processes, including stress responses, inflammation, and apoptosis. PSK2 is predominantly expressed in testis, with lower expression levels found in placenta, colon, brain, and skeletal muscle, and localizes in cytoplasm. PSK2 functions by phosphorylating MEK-3, which subsequently activates p38 MAP kinase pathway, thereby influencing cell survival and differentiation. PSK2 can activate JNK, leading to JNK-dependent morphological changes that promote apoptosis. Upon activation of caspases, PSK2 is cleaved by caspase-3, which further underscores PSK2′s role in programmed cell death. This multifaceted involvement in critical cellular functions makes PSK2 a significant target for research in cancer and other diseases where cell signaling is disrupted.

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PSK2 Antibody (22) References:

1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.  |  Nagase, T., et al. 2000. DNA Res. 7: 65-73. PMID: 10718198
2. kin-18, a C. elegans protein kinase involved in feeding.  |  Berman, KS., et al. 2001. Gene. 279: 137-47. PMID: 11733138
3. MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1.  |  Timm, T., et al. 2003. EMBO J. 22: 5090-101. PMID: 14517247
4. Molecular genetic analysis of a de novo balanced translocation t(6;17)(p21.31;q11.2) associated with hypospadias and anorectal malformation.  |  Mansouri, MR., et al. 2006. Hum Genet. 119: 162-8. PMID: 16395596
5. Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1.  |  Zihni, C., et al. 2006. J Biol Chem. 281: 7317-23. PMID: 16407310
6. A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.  |  Draviam, VM., et al. 2007. Nat Cell Biol. 9: 556-64. PMID: 17417629
7. Human TAO kinase 1 induces apoptosis in SH-SY5Y cells.  |  Wu, MF. and Wang, SG. 2008. Cell Biol Int. 32: 151-6. PMID: 17900936
8. Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton.  |  Johne, C., et al. 2008. Mol Biol Cell. 19: 1391-403. PMID: 18216281

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PSK2 Antibody (22) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PSK2 Antibody (22) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PSK2 Antibody (22) Specifications

Alternate Product Name: PSK2

Product Clone Name: 22

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 352-550

Epitope Target: PSK2

Epitope Species: rat

Product Reactivity/Detection: PSK2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PSK2 Antibody (22): N/A