PSIP1 Antibody (26): sc-136227
- PSIP1 Antibody (26) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 85-188 of PSIP1 of human origin
- recommended for detection of PSIP1 of human origin by WB, IP and IF
- m-IgGκ BP-HRP is the preferred secondary detection reagent for PSIP1 Antibody (26) for WB applications. This reagent is now offered in a bundle with PSIP1 Antibody (26) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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SEE ALSO...
PSIP1 Antibody (26) is a mouse monoclonal IgG1 antibody that detects PSIP1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). PSIP1, also known as CLL-associated antigen KW-7, LEDGF, and transcriptional coactivator p75/p52, is a crucial 530 amino acid nuclear protein that plays a significant role in the regulation of gene expression by acting as a transcriptional coactivator. PSIP1′s primary function involves forming a complex with the human immunodeficiency virus type 1 (HIV-1) integrase, which is essential for the nuclear localization and chromosomal association of viral proteins. This interaction is vital for the effective integration of viral DNA into the host genome, making PSIP1 a key player in the life cycle of HIV-1. Additionally, PSIP1′s role as the main integrase-to-chromatin tethering factor for HIV-1 underscores PSIP1′s importance in the cellular trafficking of lentiviral integrases, thereby influencing viral replication and pathogenesis. Notably, during apoptosis, PSIP1 is cleaved by caspase-3 and caspase-7, which can contribute to the development of atopic disorders, highlighting PSIP1′s multifaceted role in both viral biology and cellular processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSIP1 Antibody (26) | sc-136227 | 200 µg/ml | $322.00 | |||
PSIP1 Antibody (26): m-IgGκ BP-HRP Bundle | sc-521344 | 200 µg Ab, 40 µg BP | $361.00 |