PSAP Antibody (E-5): sc-390184
- PSAP Antibody (E-5) is a mouse monoclonal IgG1 κ PSAP antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 361-660 mapping within an internal region of PSAP of human origin
- PSAP Antibody (E-5) is recommended for detection of PSAP of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PSAP Antibody (E-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PSAP Antibody (E-5) for WB applications. These reagents are now offered in bundles with PSAP Antibody (E-5) (see ordering information below).
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SEE ALSO...
PSAP Antibody (E-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects PSAP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PSAP (E-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Puromycin-sensitive aminopeptidase (PSA or PSAP) is a 100 kDa zinc metallopeptidase that plays a crucial role in the degradation of neuropeptides by cleaving amino acid residues from the amino-terminus, which is essential for regulating neuropeptide activity and maintaining proper neuronal function. While PSAP is the most abundant aminopeptidase in the brain, PSAP presence is not limited to this organ; PSAP is primarily localized in the cytoplasm and is involved in the metabolism of neuropeptides within nerve terminals and synaptic clefts, highlighting PSAP importance in neurotransmission and synaptic plasticity. The human PSA gene is located on chromosome 17q 2-32, further emphasizing PSAP relevance in genetic studies and potential implications in neurological disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PSAP Antibody (E-5) References:
- Human puromycin-sensitive aminopeptidase: cloning of 3' UTR, evidence for a polymorphism at a.a. 140 and refined chromosomal localization to 17q21. | Bauer, WO., et al. 2001. Cytogenet Cell Genet. 92: 221-4. PMID: 11435692
- Axonal transport of puromycin-sensitive aminopeptidase in rat sciatic nerves. | Yamamoto, M., et al. 2002. Neurosci Res. 42: 133-40. PMID: 11849732
- Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells. | Kakuta, H., et al. 2003. Bioorg Med Chem Lett. 13: 83-6. PMID: 12467622
- Proteolytic cleavage of the puromycin-sensitive aminopeptidase generates a substrate binding domain. | Ma, Z., et al. 2003. Arch Biochem Biophys. 415: 80-6. PMID: 12801515
- Analysis of conserved residues of the human puromycin-sensitive aminopeptidase. | Thompson, MW. and Hersh, LB. 2003. Peptides. 24: 1359-65. PMID: 14706550
- Puromycin-sensitive aminopeptidase. Sequence analysis, expression, and functional characterization. | Constam, DB., et al. 1995. J Biol Chem. 270: 26931-9. PMID: 7592939
- Changes in puromycin-sensitive aminopeptidases in postmortem schizophrenic brain regions. | Hui, M., et al. 1995. Neurochem Int. 27: 433-41. PMID: 8845744
- Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons. | Tobler, AR., et al. 1997. J Neurochem. 68: 889-97. PMID: 9048733
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSAP Antibody (E-5) | sc-390184 | 200 µg/ml | $322.00 | |||
PSAP Antibody (E-5): m-IgG Fc BP-HRP Bundle | sc-530087 | 200 µg Ab; 10 µg BP | $361.00 | |||
PSAP Antibody (E-5): m-IgGκ BP-HRP Bundle | sc-523439 | 200 µg Ab, 40 µg BP | $361.00 | |||
PSAP Antibody (E-5): m-IgG1 BP-HRP Bundle | sc-543862 | 200 µg Ab; 20 µg BP | $361.00 | |||
PSAP Antibody (E-5) AC | sc-390184 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PSAP Antibody (E-5) HRP | sc-390184 HRP | 200 µg/ml | $322.00 | |||
PSAP Antibody (E-5) FITC | sc-390184 FITC | 200 µg/ml | $336.00 | |||
PSAP Antibody (E-5) PE | sc-390184 PE | 200 µg/ml | $349.00 | |||
PSAP Antibody (E-5) Alexa Fluor® 488 | sc-390184 AF488 | 200 µg/ml | $364.00 | |||
PSAP Antibody (E-5) Alexa Fluor® 546 | sc-390184 AF546 | 200 µg/ml | $364.00 | |||
PSAP Antibody (E-5) Alexa Fluor® 594 | sc-390184 AF594 | 200 µg/ml | $364.00 | |||
PSAP Antibody (E-5) Alexa Fluor® 647 | sc-390184 AF647 | 200 µg/ml | $364.00 | |||
PSAP Antibody (E-5) Alexa Fluor® 680 | sc-390184 AF680 | 200 µg/ml | $364.00 | |||
PSAP Antibody (E-5) Alexa Fluor® 790 | sc-390184 AF790 | 200 µg/ml | $364.00 |