PSA/KLK3/Kallikrein 3/Prostate Specific Antigen Antibody (A67-B/E3): sc-7316

PSA Antibody (A67-B/E3) is a mouse monoclonal IgG1 kappa light chain antibody that detects prostate specific antigen (PSA) of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-PSA antibody (A67-B/E3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Prostate specific antigen, also known as kallikrein-related peptidase 3 (KLK3), is a serine protease primarily produced in the prostate gland, where PSA plays a crucial role in the liquefaction of semen by hydrolyzing semenogelin I, a major protein in seminal plasma. This enzymatic activity is vital for male fertility, as PSA allows sperm to swim freely after ejaculation. Elevated levels of PSA in the blood are often associated with prostate cancer, making PSA a key biomarker for early detection and monitoring of the disease. Additionally, PSA has been found in other tissues, including breast tissue, highlighting PSA′s potential role in various cancers. PSA monoclonal antibody (A67-B/E3) accurately detects this important protein across multiple applications, making PSA (A67-B/E3) antibody an essential tool for researchers studying prostate health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

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PSA/KLK3/Kallikrein 3/Prostate Specific Antigen Antibody (A67-B/E3) References:

1. Prostate-specific antigen (PSA) in women.  |  Yu, H. and Berkel, H. 1999. J La State Med Soc. 151: 209-13. PMID: 10234897
2. Human prostate-specific antigen: structural and functional similarity with serine proteases.  |  Watt, KW., et al. 1986. Proc Natl Acad Sci U S A. 83: 3166-70. PMID: 2422647
3. Molecular cloning of human prostate specific antigen cDNA.  |  Lundwall, A. and Lilja, H. 1987. FEBS Lett. 214: 317-22. PMID: 2436946
4. Limitations of Prostate-specific Antigen Testing After a Prostate Cancer Diagnosis.  |  Caram, ME., et al. 2016. Eur Urol. 70: 209-10. PMID: 26776937
5. A novel classification of prostate specific antigen (PSA) biosensors based on transducing elements.  |  Najeeb, MA., et al. 2017. Talanta. 168: 52-61. PMID: 28391865
6. Isolation, characterization and amino-acid sequence of gamma-seminoprotein, a glycoprotein from human seminal plasma.  |  Schaller, J., et al. 1987. Eur J Biochem. 170: 111-20. PMID: 3691515
7. Biochemistry of prostate specific antigen, PSA.  |  Malm, J. and Lilja, H. 1995. Scand J Clin Lab Invest Suppl. 221: 15-22. PMID: 7544481
8. Detection of organ-confined prostate cancer is increased through prostate-specific antigen-based screening.  |  Catalona, WJ., et al. 1993. JAMA. 270: 948-54. PMID: 7688438
9. Biochemical characteristics and recent biological knowledge on prostate-specific antigen.  |  Seregni, E., et al. 1996. Tumori. 82: 72-7. PMID: 8623511
10. Purification and characterization of the active precursor of a human sperm motility inhibitor secreted by the seminal vesicles: identity with semenogelin.  |  Robert, M. and Gagnon, C. 1996. Biol Reprod. 55: 813-21. PMID: 8879494
11. Characterization of prostate-specific antigen proteolytic activity on its major physiological substrate, the sperm motility inhibitor precursor/semenogelin I.  |  Robert, M., et al. 1997. Biochemistry. 36: 3811-9. PMID: 9092810
12. Prostate-specific antigen and early detection of prostate cancer.  |  Chu, TM. 1997. Tumour Biol. 18: 123-34. PMID: 9222310

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PSA/KLK3/Kallikrein 3/Prostate Specific Antigen Antibody (A67-B/E3) has 91 citations in a variety of scientific publications.

Primary antibodies like Anti-PSA/KLK3/Kallikrein 3/Prostate Specific Antigen Antibody (A67-B/E3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PSA/KLK3/Kallikrein 3/Prostate Specific Antigen Antibody (A67-B/E3) Specifications

Alternate Product Name: PSA (prostate specific antigen)

Product Clone Name: A67-B/E3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-261

Epitope Target: PSA

Epitope Species: human

Product Reactivity/Detection: PSA

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 91 citations in various scientific publications

Available Conjugates/Forms for PSA/KLK3/Kallikrein 3/Prostate Specific Antigen Antibody (A67-B/E3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin