PSA Inhibitors
Common PSA Inhibitors include, but are not limited to Finasteride CAS 98319-26-7, Dutasteride CAS 164656-23-9, Bicalutamide CAS 90357-06-5, Flutamide CAS 13311-84-7 and Cyproterone CAS 2098-66-0.
PSA inhibitors belong to a specific chemical class of compounds designed to target and inhibit the activity of Prostate-Specific Antigen (PSA), also known as kallikrein-related peptidase 3 (KLK3). PSA is a serine protease enzyme produced predominantly by the prostate gland and is involved in the proteolytic cleavage of seminal fluid proteins to aid in liquefaction of semen and facilitate sperm motility. PSA is commonly used as a biomarker for prostate health and disease, such as prostate cancer.
PSA inhibitors work by specifically targeting the PSA enzyme, interfering with its proteolytic activity and its ability to cleave specific protein substrates. By doing so, these inhibitors may modulate the processing of seminal fluid proteins and influence processes related to sperm function and reproduction. Research into PSA inhibitors is ongoing to unravel their precise mechanisms of action and explore their implications in understanding protein processing and reproductive biology. The study of PSA inhibitors contributes to a deeper understanding of the intricate mechanisms governing male reproductive physiology.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Finasteride | 98319-26-7 | sc-203954 | 50 mg | $105.00 | 3 | |
Inhibits 5-alpha reductase enzyme, reducing conversion of testosterone to dihydrotestosterone (DHT), which can stimulate PSA production. | ||||||
Dutasteride | 164656-23-9 | sc-207600 | 10 mg | $167.00 | 2 | |
Blocks both type I and type II 5-alpha reductase enzymes, further reducing DHT production and PSA levels. | ||||||
Abiraterone | 154229-19-3 | sc-460288 | 10 mg | $276.00 | ||
Inhibits CYP17 enzyme, critical for androgen synthesis, leading to reduced androgen availability and subsequent decrease in PSA. | ||||||
MDV3100 | 915087-33-1 | sc-364354 sc-364354A | 5 mg 50 mg | $245.00 $1051.00 | 7 | |
Acts as an androgen receptor antagonist, preventing binding of androgens and subsequent PSA expression. | ||||||
Bicalutamide | 90357-06-5 | sc-202976 sc-202976A | 100 mg 500 mg | $42.00 $146.00 | 27 | |
Competitively inhibits androgen receptors, preventing androgen-induced PSA production. | ||||||
Apalutamide | 956104-40-8 | sc-507442 | 5 mg | $290.00 | ||
An androgen receptor inhibitor, decreasing the transcription of genes, including PSA, regulated by androgen receptors. | ||||||
Flutamide | 13311-84-7 | sc-204757 sc-204757A sc-204757D sc-204757B sc-204757C | 1 g 5 g 25 g 500 g 1 kg | $47.00 $156.00 $171.00 $525.00 $941.00 | 4 | |
Binds to androgen receptors, impeding androgen-mediated PSA synthesis and secretion. | ||||||
Cyproterone | 2098-66-0 | sc-278913 sc-278913A sc-278913B sc-278913C sc-278913D | 25 mg 50 mg 100 mg 250 mg 1 g | $153.00 $235.00 $296.00 $439.00 $1173.00 | ||
Acts as an androgen receptor antagonist, lowering PSA production by inhibiting androgen binding. | ||||||
Galeterone | 851983-85-2 | sc-364495 sc-364495A | 5 mg 25 mg | $191.00 $572.00 | 1 | |
Disrupts androgen receptor signaling and inhibits CYP17 enzyme, leading to decreased androgen synthesis and PSA production. | ||||||
Triptorelin | 57773-63-4 | sc-396102 | 10 mg | $241.00 | ||
Similar to leuprolide, it initially stimulates LH and FSH release, followed by decreased LH release due to desensitization of the pituitary gland. | ||||||