pS2 Antibody (A-8): sc-390889
- pS2 Antibody (A-8) is a mouse monoclonal mouse IgG3 κ κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 56-81 at the C-terminus of pS2 of human origin
- recommended for detection of precursor and mature pS2, SP and ITF of human origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for pS2 Antibody (A-8) for WB applications. This reagent is now offered in a bundle with pS2 Antibody (A-8) (see ordering information below).
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SEE ALSO...
pS2 Antibody (A-8) is a mouse monoclonal IgG3 antibody that detects pS2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). pS2, also known as Md2, BCEI, TFF1, and pNR-2, is a trefoil protein that plays a crucial role in mucosal healing and is characterized by a unique structure, which includes three intrachain disulfide bonds forming the trefoil motif, or P-domain. This structural feature contributes to pS2′s stability and resistance to proteolytic degradation, allowing pS2 to function effectively in the harsh environment of the gastrointestinal tract. pS2 is predominantly expressed in normal gastric mucosa and has been implicated in various carcinomas, including those of the breast, pancreas, and stomach. Notably, pS2 is absent in normal breast tissue but can be induced by estrogen in MCF7 cells, highlighting pS2′s potential role in cancer biology. Additionally, pS2 forms dimers, a process believed to enhance protective and healing properties, making pS2 an important target for research in gastrointestinal health and cancer. The gene encoding pS2 is located on human chromosome 21q22.3, further emphasizing pS2′s relevance in human health and disease.
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pS2 Antibody (A-8) References:
- Prognostic significance of cytosolic pS2 protein content in gastric cancer. | Suárez, C., et al. 2001. Int J Biol Markers. 16: 37-44. PMID: 11288953
- Immunohistochemical detection of pS2 protein and heat shock protein-70 in pancreatic adenocarcinomas. Relationship with disease extent and patient survival. | Sagol, O., et al. 2002. Pathol Res Pract. 198: 77-84. PMID: 11928868
- pS2 protein detected by immunohistochemistry in archival primary breast cancer. | Tutschek, B., et al. 1996. Oncol Rep. 3: 759-64. PMID: 21594450
- Characterization of the estrogen-induced pS2 protein secreted by the human breast cancer cell line MCF-7. | Nunez, AM., et al. 1987. Endocrinology. 121: 1759-65. PMID: 3665845
- Correlation between pS2 protein positivity, steroid receptor status and other prognostic factors in breast cancer. | Racca, S., et al. 1995. Int J Biol Markers. 10: 87-93. PMID: 7561244
- Prognostic significance of pS2 protein expression in pulmonary adenocarcinoma. | Higashiyama, M., et al. 1994. Eur J Cancer. 30A: 792-7. PMID: 7917539
- Expression of pS2 protein in transitional cell bladder tumours. | Lipponen, PK. and Eskelinen, MJ. 1994. J Pathol. 173: 327-32. PMID: 7965392
- Immunohistochemical localisation of pS2 protein in ductal carcinoma in situ and benign lesions of the breast. | Luqmani, YA., et al. 1993. Br J Cancer. 67: 749-53. PMID: 8385977
- pS2 protein expression in gastric carcinoma. An immunohistochemical and immunoradiometric study. | Machado, JC., et al. 1996. Eur J Cancer. 32A: 1585-90. PMID: 8911122
- Expression of pS2 protein in endometrial carcinomas: correlation with clinicopathologic features and sex steroid receptor status. | Koshiyama, M., et al. 1997. Int J Cancer. 74: 237-44. PMID: 9221798
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
pS2 Antibody (A-8) | sc-390889 | 200 µg/ml | $322.00 | |||
pS2 Antibody (A-8): m-IgG3 BP-HRP Bundle | sc-550485 | 200 µg Ab; 40 µg BP | $361.00 | |||
pS2 (A-8) Neutralizing Peptide | sc-390889 P | 100 µg/0.5 ml | $69.00 |