PRX VI Antibody (A-11): sc-393024

PRX VI Antibody (A-11) is a mouse monoclonal IgG2a antibody that detects peroxiredoxin VI in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PRX VI, also known as antioxidant protein 2, is a unique member of the peroxiredoxin family, characterized by its 1-Cys structure, which allows PRX VI to function independently of other peroxiredoxins. Peroxiredoxin VI plays a crucial role in cellular antioxidant defense, particularly in epithelial cells, where peroxiredoxin VI protects against oxidative stress by scavenging reactive oxygen species. Additionally, peroxiredoxin VI is involved in lung phospholipid metabolism and has been shown to safeguard keratinocytes from oxidative-induced cell death, highlighting peroxiredoxin VI′s importance in maintaining cellular integrity under stress conditions. PRX VI expression is widespread across various tissues, making peroxiredoxin VI a valuable target for studying oxidative stress-related diseases and cellular responses to environmental challenges. With versatile applications and significant biological role, anti-PRX VI antibody (A-11) is an essential tool for researchers investigating the mechanisms of oxidative stress and its implications in health and disease.

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PRX VI Antibody (A-11) References:

1. Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat.  |  Mitsumoto, A., et al. 2001. Free Radic Res. 35: 301-10. PMID: 11697128
2. Recombinant human peroxiredoxin VI: preparation and protective properties in vitro.  |  Merkulova, MI., et al. 2002. Biochemistry (Mosc). 67: 1235-9. PMID: 12495419
3. Role of the PLA2-independent peroxiredoxin VI activity in the survival of immortalized fibroblasts exposed to cytotoxic oxidative stress.  |  Salmon, M., et al. 2004. FEBS Lett. 557: 26-32. PMID: 14741336
4. Peroxiredoxins, a novel protein family in lung cancer.  |  Lehtonen, ST., et al. 2004. Int J Cancer. 111: 514-21. PMID: 15239128
5. Peroxiredoxins in the lung with emphasis on peroxiredoxin VI.  |  Schremmer, B., et al. 2007. Subcell Biochem. 44: 317-44. PMID: 18084901
6. Nitrosative stress leads to protein glutathiolation, increased s-nitrosation, and up-regulation of peroxiredoxins in the heart.  |  Reinartz, M., et al. 2008. J Biol Chem. 283: 17440-9. PMID: 18426799
7. Hydroxyurea-induced expression of glutathione peroxidase 1 in red blood cells of individuals with sickle cell anemia.  |  Cho, CS., et al. 2010. Antioxid Redox Signal. 13: 1-11. PMID: 19951064
8. Autoantibodies as potential biomarkers for the early detection of esophageal squamous cell carcinoma.  |  Xu, YW., et al. 2014. Am J Gastroenterol. 109: 36-45. PMID: 24296751
9. Peroxiredoxin VI oxidation in cerebrospinal fluid correlates with traumatic brain injury outcome.  |  Manevich, Y., et al. 2014. Free Radic Biol Med. 72: 210-21. PMID: 24726861
10. Autoantibody Signatures Combined with Epstein-Barr Virus Capsid Antigen-IgA as a Biomarker Panel for the Detection of Nasopharyngeal Carcinoma.  |  Peng, YH., et al. 2015. Cancer Prev Res (Phila). 8: 729-36. PMID: 25990085

The preferred PRX VI antibody is PRX VI Antibody (D-9): sc-166454.