PRX VI Antibody (D-9): sc-166454
- PRX VI Antibody (D-9) is a mouse monoclonal IgG3 κ PRX VI antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 92-109 within an internal region of PRX VI of human origin
- PRX VI Antibody (D-9) is recommended for detection of PRX VI of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-PRX VI Antibody (D-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG3 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PRX VI Antibody (D-9) for WB and IHC(P) applications. These reagents are now offered in bundles with PRX VI Antibody (D-9) (see ordering information below).
PRX VI Antibody (D-9) is a mouse monoclonal IgG3 kappa light chain antibody that detects PRX VI protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PRX VI (D-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PRX VI protein, also known as antioxidant protein 2 or AOP2, plays a crucial role in cellular antioxidant defense, particularly in epithelial cells, where PRX VI is highly expressed. PRX VI protein is unique among the peroxiredoxin family as a 1-Cys peroxiredoxin, which allows PRX VI to effectively neutralize reactive oxygen species (ROS) and protect cells from oxidative stress. Additionally, PRX VI is involved in lung phospholipid metabolism and provides protection to keratinocytes from cell death induced by ROS, highlighting PRX VI′s importance in maintaining cellular integrity and function. PRX VI localization in the cytosol is significant, as PRX VI allows for rapid response to oxidative stress within the cell, thereby contributing to cellular homeostasis and survival. Given these diverse roles, PRX VI is not only essential for antioxidant defense but also plays a part in various physiological processes, making PRX VI a valuable target for research in oxidative stress-related diseases and conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PRX VI Antibody (D-9) References:
- Peroxiredoxin I (macrophage 23 kDa stress protein) is highly and widely expressed in the rat nervous system. | Mizusawa, H., et al. 2000. Neurosci Lett. 283: 57-60. PMID: 10729633
- From cytoprotection to tumor suppression: the multifactorial role of peroxiredoxins. | Butterfield, LH., et al. 1999. Antioxid Redox Signal. 1: 385-402. PMID: 11233141
- Overexpression of peroxiredoxin in human breast cancer. | Noh, DY., et al. 2001. Anticancer Res. 21: 2085-90. PMID: 11497302
- Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome. | Kim, SH., et al. 2001. J Neural Transm Suppl. 223-35. PMID: 11771746
- Cell specific expression of peroxiredoxins in human lung and pulmonary sarcoidosis. | Kinnula, VL., et al. 2002. Thorax. 57: 157-64. PMID: 11828047
- Peroxiredoxins. | Hofmann, B., et al. 2002. Biol Chem. 383: 347-64. PMID: 12033427
- Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein. | Fujii, J. and Ikeda, Y. 2002. Redox Rep. 7: 123-30. PMID: 12189041
- Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress. | Wang, X., et al. 2003. J Biol Chem. 278: 25179-90. PMID: 12732627
- Purification, characterization, and cloning of a heme-binding protein (23 kDa) in rat liver cytosol. | Iwahara, S., et al. 1995. Biochemistry. 34: 13398-406. PMID: 7577926
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PRX VI Antibody (D-9) | sc-166454 | 200 µg/ml | $322.00 | |||
PRX VI Antibody (D-9): m-IgGκ BP-HRP Bundle | sc-521616 | 200 µg Ab, 40 µg BP | $361.00 | |||
PRX VI Antibody (D-9): m-IgG3 BP-HRP Bundle | sc-550333 | 200 µg Ab; 40 µg BP | $361.00 | |||
PRX VI Antibody (D-9) AC | sc-166454 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PRX VI Antibody (D-9) HRP | sc-166454 HRP | 200 µg/ml | $322.00 | |||
PRX VI Antibody (D-9) FITC | sc-166454 FITC | 200 µg/ml | $336.00 | |||
PRX VI Antibody (D-9) PE | sc-166454 PE | 200 µg/ml | $349.00 | |||
PRX VI Antibody (D-9) Alexa Fluor® 488 | sc-166454 AF488 | 200 µg/ml | $364.00 | |||
PRX VI Antibody (D-9) Alexa Fluor® 546 | sc-166454 AF546 | 200 µg/ml | $364.00 | |||
PRX VI Antibody (D-9) Alexa Fluor® 594 | sc-166454 AF594 | 200 µg/ml | $364.00 | |||
PRX VI Antibody (D-9) Alexa Fluor® 647 | sc-166454 AF647 | 200 µg/ml | $364.00 | |||
PRX VI Antibody (D-9) Alexa Fluor® 680 | sc-166454 AF680 | 200 µg/ml | $364.00 | |||
PRX VI Antibody (D-9) Alexa Fluor® 790 | sc-166454 AF790 | 200 µg/ml | $364.00 | |||
PRX VI (D-9) Neutralizing Peptide | sc-166454 P | 100 µg/0.5 ml | $69.00 |