PRPK Antibody (G-10): sc-398705

PRPK Antibody (G-10) is a mouse monoclonal IgG1 antibody that detects PRPK in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PRPK, or p53-related protein kinase, is a crucial 253 amino acid protein kinase that plays a significant role in the regulation of the tumor suppressor protein p53 by phosphorylating it at Ser15. This phosphorylation event enhances the stability and activity of p53, which is essential for promoting growth arrest and apoptosis in response to cellular stress signals. The proper functioning of p53 is critical for maintaining cellular integrity and preventing uncontrolled cell proliferation, making PRPK an important player in cancer biology. PRPK is predominantly localized in the nucleus, where PRPK exerts regulatory effects, and is highly expressed in the testis, with lower levels found in the heart, kidney, and spleen. Anti-PRPK antibody (G-10) facilitates the study of PRPK′s role in p53 regulation and implications in various biological processes and diseases.

The preferred PRPK antibody is PRPK Antibody (C-1): sc-514703.