Profilin-1 Antibody (H-4): sc-137236
- Profilin-1 Antibody (H-4) is a mouse monoclonal IgM κ, cited in 6 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-37 at the N-terminus of Profilin-1 of human origin
- recommended for detection of Profilin-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, bovine and porcine
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Profilin-1 Antibody (H-4) for WB applications. This reagent is now offered in a bundle with Profilin-1 Antibody (H-4) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Profilin-1 Antibody (H-4) is a mouse monoclonal IgM antibody that detects Profilin-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Profilin-1 plays a crucial role in regulating actin polymerization by binding to and sequestering actin monomers, which is essential for various cellular processes, including cell motility, shape, and division. Profilin-1 acts as a nucleotide exchange factor, facilitating the loading of ATP onto actin monomers, thereby promoting their incorporation into growing actin filaments. Profilin-1 is predominantly expressed in tissues such as the lung, liver, placenta, and kidney, highlighting its importance in both structural and functional cellular dynamics. Notably, Profilin-1′s interaction with other proteins, such as dynamin I and synapsin in the axonal and dendritic processes of the mouse brain, suggests involvement in synaptic function and neuronal signaling. Additionally, Profilin-1 overexpression in endothelial cells has been linked to enhanced adhesion to fibronectin, indicating a potential role in cell adhesion mechanisms. Given significance in various biological processes and implications in conditions like food allergies, where plant Profilin is recognized as a pan-allergen, anti-Profilin-1 antibody (H-4) serves as a valuable tool for researchers investigating the multifaceted roles of this protein in health and disease.
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Profilin-1 Antibody (H-4) References:
- Profilin-1 promotes the development of hypertension-induced artery remodeling. | Wang, Y., et al. 2014. J Histochem Cytochem. 62: 298-310. PMID: 24399041
- Profilin‑1 contributes to cardiac injury induced by advanced glycation end‑products in rats. | Yang, D., et al. 2017. Mol Med Rep. 16: 6634-6641. PMID: 28901418
- Profilin 1 Protein and Its Implications for Cancers. | Wang, Y., et al. 2021. Oncology (Williston Park). 35: 402-409. PMID: 34264570
- Profilin-1 is involved in macroangiopathy induced by advanced glycation end products via vascular remodeling and inflammation. | Xiao, ZL., et al. 2021. World J Diabetes. 12: 1875-1893. PMID: 34888013
- Cofilin-1 and profilin-1 expression in lung microvascular endothelial cells exposed to titanium dioxide nanoparticles. | An, MH., et al. 2022. Adv Clin Exp Med. 31: 1255-1264. PMID: 36000878
- Vascular endothelial profilin-1 drives a protumorigenic tumor microenvironment and tumor progression in renal cancer. | Gau, D., et al. 2023. J Biol Chem. 299: 105044. PMID: 37451478
- Prolonged depletion of profilin 1 or F-actin causes an adaptive response in microtubules. | Cisterna, BA., et al. 2024. J Cell Biol. 223: PMID: 38722279
- Neurofilament light chain and profilin-1 dynamics in 30 spinal muscular atrophy type 3 patients treated with nusinersen. | Musso, G., et al. 2024. Eur J Neurol. 31: e16393. PMID: 38924263
- The actin binding protein profilin 1 localizes inside mitochondria and is critical for their function. | Read, TA., et al. 2024. EMBO Rep. 25: 3240-3262. PMID: 39026010
- m6A Modification of Profilin-1 in Vascular Smooth Muscle Cells Drives Phenotype Switching and Neointimal Hyperplasia via Activation of the p-ANXA2/STAT3 Pathway. | Gao, XF., et al. 2024. Arterioscler Thromb Vasc Biol. 44: 2543-2559. PMID: 39508106
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Profilin-1 Antibody (H-4) | sc-137236 | 200 µg/ml | $322.00 | |||
Profilin-1 Antibody (H-4): m-IgGκ BP-HRP Bundle | sc-551979 | 200 µg Ab; 40 µg BP | $361.00 | |||
Profilin-1 (H-4) Neutralizing Peptide | sc-137236 P | 100 µg/0.5 ml | $69.00 |