PRL-R Antibody (B10): sc-74520

PRL-R Antibody (B10) is a mouse monoclonal IgG2a kappa light chain antibody that detects PRL-R protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PRL-R monoclonal antibody (B10) was raised against amino acids 91-260 mapping within an extracellular domain of PRL-R of mouse origin. PRL-R (B10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PRL-R, a member of the cytokine receptor superfamily, is crucial for mediating prolactin effects, a hormone involved in numerous physiological processes such as lactation, immune regulation, and cell growth. PRL-R is primarily located on target cell surfaces, where PRL-R plays a vital role in signal transduction through ligand-induced homodimerization, activating the JAK/Stat pathway. This pathway is essential for proliferation and differentiation of various cell types, including mammary epithelial cells, which are critical for proper mammary gland development and function. Dysregulation of PRL-R signaling has been implicated in several diseases, including breast cancer and autoimmune disorders, highlighting PRL-R importance in both normal physiology and disease states. The gene encoding human PRL-R is located on chromosome 5p13.2, and understanding PRL-R function and interactions can provide valuable insights into therapeutic targets for related conditions.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PRL-R Antibody (B10) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-PRL-R Antibody (B10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PRL-R Antibody (B10) Specifications

Alternate Product Name: Prolactin Receptor

Product Clone Name: B10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 91-260

Epitope Target: PRL-R

Epitope Species: mouse

Product Reactivity/Detection: PRL-R isoforms 1-3

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a in 1.0 ml of PBS containing 0.1% sodium azide and 0.2% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for PRL-R Antibody (B10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred PRL-R antibody is PRL-R Antibody (D-7): sc-377098.