Date published: 2026-7-18

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PRL-R Activators

PRL-R Activators, short for Prolactin Receptor Activators, belong to a distinct chemical class known for their ability to modulate the activity of prolactin receptors in various biological systems. Prolactin receptors are primarily found in the mammary glands and play a pivotal role in the regulation of lactation in mammals. Activating these receptors is crucial for initiating and sustaining milk production in nursing mothers. PRL-R Activators are compounds that specifically interact with these receptors, thereby influencing the downstream signaling pathways and cellular responses associated with prolactin receptor activation.

At a molecular level, PRL-R Activators typically possess structural features that allow them to bind to the prolactin receptor with high affinity. These compounds may mimic the binding of endogenous prolactin hormone to its receptor or function as allosteric modulators, altering the receptor's conformation and thereby affecting its signaling cascade. While their specific mechanisms of action may vary, the ultimate result is an enhancement of the biological effects associated with prolactin receptor activation. PRL-R Activators can be utilized as valuable tools in scientific research to explore the intricate functions of prolactin receptors in various physiological contexts, ranging from reproduction and lactation to immune regulation and tissue development. Understanding the mechanisms by which these compounds activate prolactin receptors can provide insights into the underlying biology of these receptors and may have implications in fields such as endocrinology, reproductive biology, and immunology, among others.

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

β-Estradiol

50-28-2sc-204431
sc-204431A
500 mg
5 g
$63.00
$182.00
8
(1)

Estradiol, a form of estrogen, can interact with estrogen receptors to modulate gene expression. This interaction can potentially lead to an increase in PRL-R expression, as estrogen has been shown to upregulate prolactin receptor levels in certain tissues.

Insulin

11061-68-0sc-29062
sc-29062A
sc-29062B
100 mg
1 g
10 g
$156.00
$1248.00
$12508.00
82
(1)

Insulin plays a critical role in cellular metabolism and growth. It has been suggested that insulin can enhance PRL-R expression, possibly by promoting cell survival and growth.

Ob (hBA-147)

sc-4912
1000 µg
$258.00
1
(0)

Leptin is a hormone involved in regulating appetite and energy balance. It has been shown to modulate prolactin secretion and may also have a role in regulating PRL-R expression.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic acid, a derivative of vitamin A, regulates cell growth and differentiation. It has been implicated in modulating PRL-R expression, possibly through its role in cellular differentiation.

1α,25-Dihydroxyvitamin D3

32222-06-3sc-202877B
sc-202877A
sc-202877C
sc-202877D
sc-202877
50 µg
1 mg
5 mg
10 mg
100 µg
$220.00
$645.00
$1000.00
$1500.00
$440.00
32
(2)

This active form of vitamin D regulates calcium and phosphate metabolism, as well as cell growth and differentiation. It has been shown to modulate prolactin and PRL-R expression in certain tissues.

Progesterone

57-83-0sc-296138A
sc-296138
sc-296138B
1 g
5 g
50 g
$20.00
$52.00
$298.00
3
(1)

Progesterone has been shown to modulate prolactin secretion and may also influence PRL-R expression.

Hydrocortisone

50-23-7sc-300810
5 g
$102.00
6
(1)

Cortisol is a glucocorticoid hormone that plays a role in stress response, metabolism, and immune regulation. It may modulate PRL-R expression as part of its wide-ranging effects on cellular function.

Dopamine

51-61-6sc-507336
1 g
$290.00
(0)

Dopamine is a neurotransmitter that has been shown to inhibit prolactin secretion. However, its role in regulating PRL-R expression is complex and may vary depending on the tissue and context.