PRDM8 Antibody (E-3): sc-390001

PRDM8 Antibody (E-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects PRDM8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PRDM8 antibody (E-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PRDM8 plays a crucial role in transcriptional regulation, which is essential for maintaining normal cellular functions and development. PRDM8 is primarily located in the nucleus, where PRDM8 influences gene expression by interacting with specific DNA sequences. Notably, PRDM8 contains three C2H2-type zinc fingers and one SET domain, which are critical for PRDM8′s function in chromatin remodeling and gene silencing. Dysregulation of PRDM8 has been implicated in various malignancies, as the balance between PR-plus and PR-minus isoforms can significantly affect cellular behavior and contribute to tumorigenesis. Understanding PRDM8′s role in these processes is vital for developing targeted therapies and improving cancer treatment outcomes.

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PRDM8 Antibody (E-3) References:

1. The yin-yang of PR-domain family genes in tumorigenesis.  |  Jiang, GL. and Huang, S. 2000. Histol Histopathol. 15: 109-17. PMID: 10668202
2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.  |  Strausberg, RL., et al. 2002. Proc Natl Acad Sci U S A. 99: 16899-903. PMID: 12477932
3. The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter.  |  Liu, L., et al. 1997. J Biol Chem. 272: 2984-91. PMID: 9006946

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PRDM8 Antibody (E-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PRDM8 Antibody (E-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PRDM8 Antibody (E-3) Specifications

Alternate Product Name: PRDM8

Product Clone Name: E-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-125

Epitope Target: PRDM8

Epitope Species: human

Product Reactivity/Detection: PRDM8

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PRDM8 Antibody (E-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent