PRDM8 Inhibitors
PRDM8 inhibitors belong to a distinctive chemical class that targets the PRDM8 protein, an epigenetic regulator with emerging significance in cellular processes. The PRDM8 gene encodes a member of the PRDM (PRDI-BF1 and RIZ homology domain) family, which is characterized by the presence of a conserved SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain. PRDM8, specifically, is known for its role as a histone methyltransferase, exerting control over gene expression through the addition of methyl groups to histone proteins. The catalytic activity of PRDM8 is implicated in the modulation of chromatin structure, impacting the accessibility of DNA to transcriptional machinery and consequently influencing diverse cellular functions.
PRDM8 function by disrupting its enzymatic activity, stopping the transfer of methyl groups to histones and thereby altering the epigenetic landscape. This chemical class typically comprises small molecules designed to selectively bind to the catalytic site of PRDM8, impeding its ability to modify histones. By interfering with the intricate process of histone methylation, PRDM8 inhibitors have the potential to influence gene expression patterns and, consequently, cellular processes regulated by these genes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Analogous to 5-Azacytidine, it inhibits DNA methyltransferases and can modify the methylation status of genes regulated by PRDM8. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
A histone deacetylase inhibitor which can modify chromatin structure, potentially influencing PRDM8's gene regulatory activity. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Another histone deacetylase inhibitor which can lead to changes in chromatin architecture, indirectly affecting PRDM8's role. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
A selective histone deacetylase inhibitor that can affect chromatin state and potentially PRDM8-mediated gene regulation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
An HDAC inhibitor that could change chromatin accessibility, possibly influencing PRDM8 action in gene regulation. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
A cyclic peptide HDAC inhibitor that may alter chromatin structure and impact PRDM8-related gene expression. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
A non-nucleoside DNA methyltransferase inhibitor, potentially impacting methylation of genes PRDM8 regulates. | ||||||
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
A product inhibitor of methyltransferase reactions, which may indirectly influence PRDM8 activity by altering methylation levels. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
A histone methyltransferase inhibitor which may indirectly affect the methylation status of PRDM8 target genes. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $126.00 | 5 | |
A specific inhibitor of histone methyltransferase that could potentially modify PRDM8-related gene expression patterns. | ||||||