PRDM11 Antibody (G-12): sc-398876
- PRDM11 Antibody (G-12) is a mouse monoclonal IgG1 κ PRDM11 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 419-447 within an internal region of PRDM11 of human origin
- PRDM11 Antibody (G-12) is recommended for detection of PRDM11 of human origin by WB, IP, IF and ELISA
- Anti-PRDM11 Antibody (G-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PRDM11 Antibody (G-12) for WB applications. These reagents are now offered in bundles with PRDM11 Antibody (G-12) (see ordering information below).
PRDM11 Antibody (G-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects PRDM11 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PRDM11 (G-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PRDM11, also known as PFM8, is a 511 amino acid protein that plays a crucial role in gene regulation and is part of the PR domain-containing protein family. This family is known for its involvement in modulating gene activities, particularly in the context of cancer. PRDM11 exists as two alternatively spliced isoforms, which produce PR-plus and PR-minus products that differ by the presence or absence of the PR domain. The PR-plus isoform is typically underexpressed or disrupted in cancer cells, while the PR-minus isoform is often overexpressed, leading to an imbalance that can be a significant factor in malignancy. The gene encoding PRDM11 is located on chromosome 11p11.2, within a region associated with liver tumor suppression, highlighting its potential importance in cancer biology and therapeutic research.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PRDM11 Antibody (G-12) References:
- The retinoblastoma protein-interacting zinc finger gene RIZ in 1p36-linked cancers. | Huang, S. 1999. Front Biosci. 4: D528-32. PMID: 10369808
- Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. | Nagase, T., et al. 1999. DNA Res. 6: 337-45. PMID: 10574462
- The yin-yang of PR-domain family genes in tumorigenesis. | Jiang, GL. and Huang, S. 2000. Histol Histopathol. 15: 109-17. PMID: 10668202
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Strausberg, RL., et al. 2002. Proc Natl Acad Sci U S A. 99: 16899-903. PMID: 12477932
- Identification of three 11p11.2 candidate liver tumor suppressors through analysis of known human genes. | Ricketts, SL., et al. 2003. Mol Carcinog. 36: 90-9. PMID: 12557265
- Essential roles of a zebrafish prdm1/blimp1 homolog in embryo patterning and organogenesis. | Wilm, TP. and Solnica-Krezel, L. 2005. Development. 132: 393-404. PMID: 15623803
- The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter. | Liu, L., et al. 1997. J Biol Chem. 272: 2984-91. PMID: 9006946
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PRDM11 Antibody (G-12) | sc-398876 | 200 µg/ml | $316.00 | |||
PRDM11 Antibody (G-12): m-IgG Fc BP-HRP Bundle | sc-530951 | 200 µg Ab; 10 µg BP | $354.00 | |||
PRDM11 Antibody (G-12): m-IgGκ BP-HRP Bundle | sc-524517 | 200 µg Ab, 40 µg BP | $354.00 | |||
PRDM11 Antibody (G-12): m-IgG1 BP-HRP Bundle | sc-544332 | 200 µg Ab; 20 µg BP | $354.00 | |||
PRDM11 Antibody (G-12) AC | sc-398876 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PRDM11 Antibody (G-12) HRP | sc-398876 HRP | 200 µg/ml | $316.00 | |||
PRDM11 Antibody (G-12) FITC | sc-398876 FITC | 200 µg/ml | $330.00 | |||
PRDM11 Antibody (G-12) PE | sc-398876 PE | 200 µg/ml | $343.00 | |||
PRDM11 Antibody (G-12) Alexa Fluor® 488 | sc-398876 AF488 | 200 µg/ml | $357.00 | |||
PRDM11 Antibody (G-12) Alexa Fluor® 546 | sc-398876 AF546 | 200 µg/ml | $357.00 | |||
PRDM11 Antibody (G-12) Alexa Fluor® 594 | sc-398876 AF594 | 200 µg/ml | $357.00 | |||
PRDM11 Antibody (G-12) Alexa Fluor® 647 | sc-398876 AF647 | 200 µg/ml | $357.00 | |||
PRDM11 Antibody (G-12) Alexa Fluor® 680 | sc-398876 AF680 | 200 µg/ml | $357.00 | |||
PRDM11 Antibody (G-12) Alexa Fluor® 790 | sc-398876 AF790 | 200 µg/ml | $357.00 | |||
PRDM11 (G-12) Neutralizing Peptide | sc-398876 P | 100 µg/0.5 ml | $68.00 |