PRDM11 Activators
PRDM11 Activators belong to a distinctive chemical class characterized by their ability to modulate the activity of PRDM11, a member of the PRDM (PRDI-BF1 and RIZ homology domain-containing) family of transcriptional regulators. PRDM11, also known as MDS1-EVI1, plays a crucial role in cellular processes such as development, differentiation, and maintenance of cell identity. These activators exert their influence by interacting with the PRDM11 protein and influencing its transcriptional regulatory functions. PRDM11 is recognized for its dual roles as both an oncogene and a tumor suppressor, depending on the cellular context. Activation of PRDM11 is implicated in various cellular pathways, including hematopoiesis and embryonic development, making PRDM11 Activators a subject of keen interest in the field of molecular biology and cellular physiology.
The chemical structure and properties of PRDM11 Activators are diverse, reflecting the intricate nature of the interactions involved in modulating PRDM11 activity. Researchers have been exploring the structural features that contribute to the specificity and affinity of these activators towards PRDM11, aiming to unravel the intricate mechanisms underlying their regulatory functions. Understanding the molecular details of PRDM11 activation holds promise for uncovering novel insights into cellular processes and may pave the way for the development of innovative strategies for manipulating gene expression patterns in a controlled manner.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels in cells. Elevated cAMP enhances PKA activity which could phosphorylate PRDM11, potentially enhancing its transcriptional regulatory functions. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, preventing cAMP degradation, thereby supporting the PKA pathway which might enhance PRDM11 activity through phosphorylation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate is another histone deacetylase inhibitor, which could enhance PRDM11 activity by a similar mechanism to Trichostatin A, promoting a chromatin environment conducive to PRDM11 binding and activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that raises intracellular calcium levels, potentially influencing calcium-dependent phosphorylation pathways that could enhance the activity of PRDM11. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This catechin inhibits DNA methyltransferases and modulates histone deacetylases, potentially enhancing PRDM11 activity by affecting the chromatin landscape and gene expression profiles. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 is a DNA methyltransferase inhibitor that can lead to demethylation of PRDM11 target gene promoters, potentially enhancing the transcriptional regulatory role of PRDM11. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
Zebularine is a cytidine analog that inhibits DNA methylation. It could enhance PRDM11's role in gene regulation by demethylation of genomic DNA at target sites. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid influences gene expression through its nuclear receptors. It could enhance PRDM11 activity by inducing epigenetic changes favoring PRDM11’s binding and regulatory functions. | ||||||