Progesterone Receptor Antibody (A-2): sc-398898
- Progesterone Receptor Antibody (A-2) is a mouse monoclonal IgG1 κ, cited in 10 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 538-571 within an internal region of PR of human origin
- Anti-Progesterone Receptor Antibody (A-2) is recommended for detection of PR-A and PR-B of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Progesterone Receptor Antibody (A-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-398898 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Progesterone Receptor Antibody (A-2) for WB applications. These reagents are now offered in bundles with Progesterone Receptor Antibody (A-2) (see ordering information below).
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SEE ALSO...
PR Antibody (A-2) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect both PR-A and PR-B isoforms of the human progesterone receptor, as well as those from mouse and rat, with exceptional accuracy in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-progesterone receptor antibody (A-2) is meticulously raised against a specific epitope mapping between amino acids 538-571 within an internal region of the human progesterone receptor, ensuring precise binding and reliable detection. The progesterone receptor is a critical nuclear hormone receptor that mediates the diverse effects of progesterone, a key hormone involved in regulating reproductive processes, including the menstrual cycle, pregnancy, and embryogenesis. Functionally, the progesterone receptor exists in two main isoforms, PR-A and PR-B, which are transcribed from distinct, estrogen-inducible promoters within a single PR gene. PR-B contains an additional 164 amino acids at its N-terminus compared to PR-A, which results in different transcriptional activation properties. PR-B generally acts as a potent transcriptional activator, promoting the expression of genes involved in cell proliferation and differentiation, while PR-A functions as a ligand-dependent transdominant repressor, modulating the activity of other steroid hormone receptors and maintaining hormonal balance within the cell. This functional divergence is crucial for the precise regulation of progesterone signaling, which is essential for maintaining reproductive health and has significant implications in conditions such as breast cancer, where progesterone receptor signaling can influence tumor growth and response to therapy. Additionally, the presence of an inhibitory domain within both PR isoforms, which is only active in PR-A, underscores the complex regulatory mechanisms that govern receptor activity and cellular responses to progesterone. Progesterone receptor monoclonal antibody (A-2) serves as an invaluable tool for researchers studying the intricate pathways of hormone signaling, reproductive biology, and hormone-related diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Progesterone Receptor Antibody (A-2) | sc-398898 | 200 µg/ml | $322.00 | |||
Progesterone Receptor Antibody (A-2): m-IgG Fc BP-HRP Bundle | sc-527829 | 200 µg Ab; 10 µg BP | $361.00 | |||
Progesterone Receptor Antibody (A-2): m-IgG1 BP-HRP Bundle | sc-533202 | 200 µg Ab; 20 µg BP | $361.00 | |||
Progesterone Receptor Antibody (A-2) X | sc-398898 X | 200 µg/0.1 ml | $322.00 | |||
Progesterone Receptor Antibody (A-2) AC | sc-398898 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Progesterone Receptor Antibody (A-2) HRP | sc-398898 HRP | 200 µg/ml | $322.00 | |||
Progesterone Receptor Antibody (A-2) FITC | sc-398898 FITC | 200 µg/ml | $336.00 | |||
Progesterone Receptor Antibody (A-2) PE | sc-398898 PE | 200 µg/ml | $349.00 | |||
Progesterone Receptor Antibody (A-2) Alexa Fluor® 488 | sc-398898 AF488 | 200 µg/ml | $364.00 | |||
Progesterone Receptor Antibody (A-2) Alexa Fluor® 546 | sc-398898 AF546 | 200 µg/ml | $364.00 | |||
Progesterone Receptor Antibody (A-2) Alexa Fluor® 594 | sc-398898 AF594 | 200 µg/ml | $364.00 | |||
Progesterone Receptor Antibody (A-2) Alexa Fluor® 647 | sc-398898 AF647 | 200 µg/ml | $364.00 | |||
Progesterone Receptor Antibody (A-2) Alexa Fluor® 680 | sc-398898 AF680 | 200 µg/ml | $364.00 | |||
Progesterone Receptor Antibody (A-2) Alexa Fluor® 790 | sc-398898 AF790 | 200 µg/ml | $364.00 | |||
Progesterone Receptor (A-2) Neutralizing Peptide | sc-398898 P | 100 µg/0.5 ml | $69.00 |