PPEF-2 Antibody (41): sc-293044

PPEF-2 Antibody (41) is a mouse monoclonal IgG2a kappa light chain antibody that detects PPEF-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-PPEF-2 antibody (41) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). PPEF-2 protein, also known as protein phosphatase, EF-hand calcium binding domain 2, is a member of the serine/threonine protein phosphatase family and plays a crucial role in the normal functioning of the visual system. PPEF-2 (41) monoclonal antibody targets proteins localized to the inner segments of photoreceptor cells in the retina and the pineal gland, where PPEF-2 is essential for sensory neuron differentiation and function. The presence of two EF-hand calcium-binding motifs in PPEF-2′s C terminus allows interaction with calcium ions, which is vital for regulatory role in cellular signaling pathways. PPEF-2 shares significant sequence similarity with the Drosophila retinal degeneration C (rdgC) gene, highlighting evolutionary conservation and importance in sensory neuron function. Expression of a 3.7-kb PPEF-2 mRNA in the rat retina underscores specific role in visual processing, making anti-PPEF-2 antibody (41) an invaluable tool for researchers studying sensory neuron biology and related disorders.

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PPEF-2 Antibody (41) References:

1. RdgC/PP5-related phosphatases: novel components in signal transduction.  |  Andreeva, AV. and Kutuzov, MA. 1999. Cell Signal. 11: 555-62. PMID: 10433516
2. Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2).  |  Ramulu, P., et al. 2001. Mol Cell Biol. 21: 8605-14. PMID: 11713293
3. Protein Ser/Thr phosphatases PPEF interact with calmodulin.  |  Kutuzov, MA., et al. 2002. Biochem Biophys Res Commun. 293: 1047-52. PMID: 12051765
4. A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin.  |  Montini, E., et al. 1997. Hum Mol Genet. 6: 1137-45. PMID: 9215685
5. Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C.  |  Sherman, PM., et al. 1997. Proc Natl Acad Sci U S A. 94: 11639-44. PMID: 9326663
6. Exclusion of PPEF as the gene causing X-linked juvenile retinoschisis.  |  van de Vosse, E., et al. 1997. Hum Genet. 101: 235-7. PMID: 9402977
7. Expression and characterization of PP7, a novel plant protein Ser/Thr phosphatase distantly related to RdgC/PPEF and PP5.  |  Kutuzov, MA., et al. 1998. FEBS Lett. 440: 147-52. PMID: 9862444

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PPEF-2 Antibody (41) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PPEF-2 Antibody (41) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PPEF-2 Antibody (41) Specifications

Alternate Product Name: PPEF-2

Product Clone Name: 41

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 614-730

Epitope Target: PPEF-2

Epitope Species: human

Product Reactivity/Detection: the long form of PPEF-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PPEF-2 Antibody (41): AC: Agarose, HRP: Horseradish Peroxidase