PP2A-Aα/β Antibody (H-11): sc-74579
- PP2A-Aα/β Antibody (H-11) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 290-589 mapping at the C-terminus of PP2A-Aα of human origin
- recommended for detection of PP2A-Aα and PP2A-Aβ of mouse, rat and human origin by WB, IP, IF and ELISA
- See PP2A-Aα (6G3): sc-56954 for PP2A-Aα/β antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PP2A-Aα/β Antibody (H-11) for WB applications. These reagents are now offered in bundles with PP2A-Aα/β Antibody (H-11) (see ordering information below).
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PP2A-Aα/β Antibody (H-11) is a mouse monoclonal IgG1 antibody that detects PP2A-Aα/β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PP2A-Aα/β is a crucial regulatory subunit of the protein phosphatase 2A (PP2A) complex, which plays a vital role in cellular signaling by dephosphorylating serine and threonine residues on target proteins. This dephosphorylation is essential for various cellular processes, including cell division, apoptosis, and maintaining cellular homeostasis. The PP2A complex is composed of a catalytic subunit and regulatory subunits, with PP2A-Aα and PP2A-Aβ being key members that modulate phosphatase activity and specificity. PP2A-Aα/β interaction with different regulatory subunits allows for diverse holoenzyme formation, which can target specific substrates, thereby influencing numerous signaling pathways. Understanding PP2A-Aα/β dynamics and interactions is critical for elucidating roles in health and disease, particularly in cancer, where dysregulation of phosphatase activity can lead to aberrant signaling and tumor progression. Anti-PP2A-Aα/β antibody (H-11) serves as an invaluable tool for researchers exploring protein phosphatase mechanisms and their impact on cellular functions.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PP2A-Aα/β Antibody (H-11) References:
- Structure, regulation, and pharmacological modulation of PP2A phosphatases. | Lambrecht, C., et al. 2013. Methods Mol Biol. 1053: 283-305. PMID: 23860660
- Regulation of PP2A by Sphingolipid Metabolism and Signaling. | Oaks, J. and Ogretmen, B. 2014. Front Oncol. 4: 388. PMID: 25642418
- All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase. | Sangodkar, J., et al. 2016. FEBS J. 283: 1004-24. PMID: 26507691
- The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias. | Pippa, R. and Odero, MD. 2020. Cells. 9: PMID: 32110991
- The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformation. | Dzulko, M., et al. 2020. Biochim Biophys Acta Rev Cancer. 1874: 188453. PMID: 33068647
- The Pivotal Role of Protein Phosphatase 2A (PP2A) in Brain Tumors. | Cucinotta, L., et al. 2022. Int J Mol Sci. 23: PMID: 36555359
- Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A. | Pavic, K., et al. 2023. Nat Commun. 14: 1143. PMID: 36854761
- Corynoxine triggers cell death via activating PP2A and regulating AKT-mTOR/GSK3β axes in NSCLC. | Hou, G., et al. 2024. Biochem Pharmacol. 222: 116110. PMID: 38460908
- The PP2A regulator IER5L supports prostate cancer progression. | Crespo, JR., et al. 2024. Cell Death Dis. 15: 514. PMID: 39025841
- Paradoxical action of PP2A inhibition and its potential for therapeutic sensitization. | Jiang, Y., et al. 2024. J Cell Physiol. 239: e31413. PMID: 39150149
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PP2A-Aα/β Antibody (H-11) | sc-74579 | 200 µg/ml | $322.00 | |||
PP2A-Aα/β Antibody (H-11): m-IgG Fc BP-HRP Bundle | sc-539553 | 200 µg Ab; 10 µg BP | $361.00 | |||
PP2A-Aα/β Antibody (H-11): m-IgG1 BP-HRP Bundle | sc-541553 | 200 µg Ab; 20 µg BP | $361.00 |