POSH Antibody (A-4): sc-376059

POSH Antibody (A-4) is a mouse monoclonal IgG1 antibody that detects POSH in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). POSH, which stands for "plenty of SH3s," is a crucial protein that contains four SH3 domains and plays a significant role in the regulation of various signaling pathways. Specifically, POSH preferentially interacts with the GTP-bound form of Rac, a member of the small GTPase family, facilitating the activation of c-Jun N-terminal kinase (JNK) and promoting the nuclear translocation of nuclear factor kappa B (NFkB). This interaction links Rac signaling to important cellular processes, including cell survival and apoptosis. POSH′s ability to induce apoptosis upon overexpression highlights its potential role in regulating cell fate decisions, making POSH an important target for studies related to cancer and other diseases where cell signaling is disrupted. Anti-POSH antibody (A-4) serves as an essential tool for researchers investigating the intricate networks of cellular signaling and the functional implications of Rac and its binding partners.

The preferred POSH antibody is POSH Antibody (E-1): sc-390103.