POPX2 Antibody (B-11): sc-393807
- POPX2 Antibody (B-11) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 204-269 mapping within an internal region of POPX2 of human origin
- recommended for detection of POPX2 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for POPX2 Antibody (B-11) for WB applications. This reagent is now offered in a bundle with POPX2 Antibody (B-11) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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POPX2 Antibody (B-11) is a mouse monoclonal IgG2b antibody that detects POPX2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). POPX2, also known as partner of PIX 2, PPM1F, or CaMKPase, is a member of the PP2C family of serine/threonine phosphatases, which play a crucial role in regulating cellular stress response pathways. POPX2 is ubiquitously expressed, participating in various cellular processes, including the modulation of calcium/calmodulin-dependent protein kinase II (CaMKII) activity, which is vital for synaptic plasticity and memory formation. POPX2′s ability to interact with and regulate CaMKII underscores its importance in neuronal signaling and potential implications in neurodegenerative diseases when dysregulated. Additionally, POPX2′s interaction with PIX proteins and role in negatively regulating αPAK activity highlight its involvement in maintaining cytoskeletal integrity and cellular morphology. POPX2 regulation of these pathways is essential for proper cellular function, and POPX2 overexpression can lead to caspase-dependent apoptosis, emphasizing its significance in cell survival and death mechanisms.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
POPX2 Antibody (B-11) | sc-393807 | 200 µg/ml | $316.00 | |||
POPX2 Antibody (B-11): m-IgGκ BP-HRP Bundle | sc-535898 | 200 µg Ab; 40 µg BP | $354.00 |