PON1 Antibody (4G8D3): sc-517274
- PON1 Antibody (4G8D3) is a mouse monoclonal IgG1 provided at 200 µg/ml
- raised against amino acids 20-155 of PON1 of human origin
- recommended for detection of PON1 of human origin by WB, IP, IF, IHC(P), FCM and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PON1 Antibody (4G8D3) for WB and IHC(P) applications. These reagents are now offered in bundles with PON1 Antibody (4G8D3) (see ordering information below).
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PON1 Antibody (4G8D3) is a mouse monoclonal IgG1 antibody that detects PON1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). PON1, or paraoxonase 1, plays a crucial role in the detoxification of organophosphates and is essential for protecting cells from oxidative stress and inflammation. PON1 is primarily located in the liver and is secreted into the bloodstream, where PON1 associates with high-density lipoproteins. PON1′s localization is significant because PON1 allows for the efficient hydrolysis of toxic compounds, thereby preventing their accumulation and potential damage to tissues. Additionally, PON1′s interaction with lipoproteins is vital for protective functions, as PON1 helps to modulate lipid metabolism and reduce the risk of cardiovascular diseases. The genes encoding PON1, along with PON2 and PON3, are clustered on human chromosome 7q21.3, highlighting their evolutionary relationship and shared regulatory mechanisms. Anti-PON1 antibody (4G8D3) is an invaluable tool for researchers studying the biochemical pathways involving organophosphate metabolism and the protective roles of paraoxonases in human health.
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PON1 Antibody (4G8D3) References:
- The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism. | Costa, LG., et al. 1999. Chem Biol Interact. 119-120: 429-38. PMID: 10421480
- Human PON1, a biomarker of risk of disease and exposure. | Furlong, CE., et al. 2010. Chem Biol Interact. 187: 355-61. PMID: 20338154
- Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity. | Costa, LG., et al. 2013. Toxicology. 307: 115-22. PMID: 22884923
- PON1 Q192R and L55M polymorphisms and organophosphate toxicity risk: a meta-analysis. | You, T., et al. 2013. DNA Cell Biol. 32: 252-9. PMID: 23590198
- PON1 L55M polymorphism might contribute to the risk of cancer. | Hu, P., et al. 2017. Panminerva Med. 59: 107-113. PMID: 27309259
- Role of polyphenols and polyphenol-rich foods in the modulation of PON1 activity and expression. | Martini, D., et al. 2017. J Nutr Biochem. 48: 1-8. PMID: 28623808
- Paraoxonase-1 (PON1) Status Analysis Using Non-Organophosphate Substrates. | Marsillach, J., et al. 2021. Curr Protoc. 1: e25. PMID: 33484495
- Abnormal paraoxonase-1 (PON1) enzyme activity in idiopathic inflammatory myopathies. | Bae, SS., et al. 2022. Rheumatology (Oxford). 61: 2512-2523. PMID: 34698804
- The Paraoxanase 1 (PON1) Gene in the Context of Coronary Artery Disease. | Pinheiro, DDS. and Jesuíno, RSA. 2022. Arq Bras Cardiol. 119: 602-603. PMID: 36287414
- The Role of Polyphenols in Modulating PON1 Activity Regarding Endothelial Dysfunction and Atherosclerosis. | Sirca, TB., et al. 2024. Int J Mol Sci. 25: PMID: 38474211
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PON1 Antibody (4G8D3) | sc-517274 | 200 µg/ml | $316.00 | |||
PON1 Antibody (4G8D3): m-IgG Fc BP-HRP Bundle | sc-541100 | 200 µg Ab; 10 µg BP | $354.00 | |||
PON1 Antibody (4G8D3): m-IgG1 BP-HRP Bundle | sc-542579 | 200 µg Ab; 20 µg BP | $354.00 |