Pol II Antibody (mara-3): sc-65884
- Pol II Antibody (mara-3) is a mouse monoclonal IgM κ, cited in 1 publications, provided at 200 µg/ml
- raised against the C-terminal domain of RNA Pol II of yeast origin
- recommended for detection of Pol II of mouse, rat and human origin by WB and IP
- See Pol II (CTD4H8): sc-47701 for Pol II antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Pol II Antibody (mara-3). This work is in progress.
QUICK LINKS
SEE ALSO...
Pol II Antibody (mara-3) is a mouse monoclonal IgM antibody that detects RNA polymerase II (Pol II) in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. Pol II is a crucial enzyme composed of twelve subunits, responsible for the transcription of protein-coding genes, which is a fundamental process for gene expression and cellular function. The largest subunit of Pol II, known as RPB1 or RPB205, is a 1,840 amino acid protein that features a C2H2-type zinc finger and a C-terminal domain rich in heptapeptide repeats. This subunit is essential for catalytic activity and plays a vital role in forming the DNA-binding domain, necessary for accurate transcription of the DNA template. RPB1′s proper function is critical; any disruption severely compromises mRNA synthesis and transcription elongation, potentially disrupting cellular processes and gene regulation. Anti-Pol II antibody (mara-3) serves as an invaluable tool for researchers studying transcription mechanisms and gene expression regulation in various biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pol II Antibody (mara-3) | sc-65884 | 200 µg/ml | $322.00 |