PNK Antibody (B-4): sc-166188
- PNK Antibody (B-4) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 222-521 mapping at the C-terminus of PNK of human origin
- recommended for detection of PNK of human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-166188 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PNK Antibody (B-4) for WB applications. These reagents are now offered in bundles with PNK Antibody (B-4) (see ordering information below).
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PNK Antibody (B-4) is a mouse monoclonal IgG1 antibody that detects polynucleotide kinase (PNK) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PNK antibody (B-4) recognizes the bifunctional polynucleotide phosphatase/kinase, which plays a crucial role in DNA repair mechanisms, particularly in response to damage from radiation or oxidative stress. PNK (B-4) monoclonal antibody enables detection of a protein essential for maintaining genomic stability, as PNK catalyzes the phosphorylation of DNA at hydroxy termini while also possessing the ability to dephosphorylate 3′-phosphate termini, thereby facilitating the proper processing of DNA ends during repair. PNK is predominantly located in the nucleus, where PNK activity is vital for the repair of single-strand breaks and the maintenance of DNA integrity. The highest expression levels of PNK are found in the testis, pancreas, spleen, kidney, and heart, highlighting PNK importance in various cellular functions and tissue-specific roles. Anti-PNK antibody (B-4) helps researchers gain insights into the dynamics of DNA repair processes and the implications of PNK in cellular responses to DNA damage.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PNK Antibody (B-4) | sc-166188 | 200 µg/ml | $322.00 | |||
PNK Antibody (B-4): m-IgG Fc BP-HRP Bundle | sc-537454 | 200 µg Ab; 10 µg BP | $361.00 | |||
PNK Antibody (B-4): m-IgGκ BP-HRP Bundle | sc-534726 | 200 µg Ab; 40 µg BP | $361.00 | |||
PNK Antibody (B-4): m-IgG1 BP-HRP Bundle | sc-545190 | 200 µg Ab; 20 µg BP | $361.00 | |||
PNK Antibody (B-4) X | sc-166188 X | 200 µg/0.1 ml | $322.00 |