PML Antibody (G-8): sc-377340
- PML Antibody (G-8) is a mouse monoclonal IgG2b κ, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 157-394 of PML of human origin
- recommended for detection of all isoforms of PML of human origin by WB, IP, IF, IHC(P) and ELISA
- TransCruz reagent for ChIP application (sc-377340 X, 200 µg/0.1 ml)
- See PML (E-11): sc-377390 for PML antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PML Antibody (G-8) for WB and IHC(P) applications. These reagents are now offered in bundles with PML Antibody (G-8) (see ordering information below).
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SEE ALSO...
PML Antibody (G-8) is a mouse monoclonal IgG2b antibody that detects PML in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PML is a crucial zinc finger transcription factor that plays a significant role in regulating gene expression and cellular differentiation. PML (G-8) antibody targets proteins predominantly located in the nucleus, where PML is involved in the formation of nuclear bodies essential for various cellular processes, including apoptosis and stress response. PML (G-8) monoclonal antibody recognizes proteins that facilitate interactions with other nuclear proteins and transcriptional regulators, thereby influencing pathways that govern cell growth and survival. Notably, PML is implicated in the pathogenesis of acute promyelocytic leukemia due to involvement in the formation of the PML/RARα chimeric protein, which disrupts normal differentiation and promotes oncogenesis. Anti-PML antibody (G-8) serves as an invaluable tool for researchers studying molecular mechanisms of PML and its role in cancer biology, providing insights into potential therapeutic targets and strategies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PML Antibody (G-8) | sc-377340 | 200 µg/ml | $322.00 | |||
PML Antibody (G-8): m-IgG Fc BP-HRP Bundle | sc-538038 | 200 µg Ab; 10 µg BP | $361.00 | |||
PML Antibody (G-8): m-IgGκ BP-HRP Bundle | sc-535562 | 200 µg Ab; 40 µg BP | $361.00 | |||
PML Antibody (G-8) X | sc-377340 X | 200 µg/0.1 ml | $322.00 |