PML Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
ATRA is a well-known PML inhibitor used in research focusing on acute promyelocytic leukemia (APL). It induces differentiation of leukemia cells and promotes degradation of the PML-RARA fusion protein, which drives APL. | ||||||
PRIMA-1MET | 5291-32-7 | sc-361295 sc-361295A | 10 mg 25 mg | $153.00 $325.00 | 5 | |
PRIMA-1 is a small molecule that restores the tumor suppressor function of mutant p53 protein by promoting the reactivation of PML nuclear bodies and subsequent apoptosis in cancer cells. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram has been investigated as a PML inhibitor that induces PML-RARA degradation in APL cells, thereby showing potential as a therapeutic agent for APL. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $272.00 | 18 | |
Tamoxifen has been explored for its potential to induce PML-RARA degradation and differentiation in APL cells. | ||||||
(–)-Nutlin-3 | 675576-98-4 | sc-222086 sc-222086A | 1 mg 5 mg | $122.00 $219.00 | 2 | |
Nutlin-3 is a compound that disrupts the interaction between p53 and MDM2, leading to PML activation and apoptosis in cancer cells. | ||||||