PLRP2 Antibody (D-1): sc-376236
- PLRP2 Antibody (D-1) is a mouse monoclonal IgG1 κ PLRP2 antibody provided at 200 µg/ml
- raised against amino acids 13-70 mapping near the N-terminus of PLRP2 of mouse origin
- PLRP2 Antibody (D-1) is recommended for detection of PLRP2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PLRP2 Antibody (D-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PLRP2 Antibody (D-1) for WB applications. These reagents are now offered in bundles with PLRP2 Antibody (D-1) (see ordering information below).
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PLRP2 Antibody (D-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects PLRP2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PLRP2 (D-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The pancreatic lipase-related protein 2 (PLRP2) is a 469 amino acid protein that shares 65% amino acid identity with pancreatic lipase, a crucial enzyme for dietary fat absorption. PLRP2 is primarily expressed in the pancreas and is secreted into the intestinal lumen, where PLRP2 plays a significant role in lipid metabolism by hydrolyzing triglycerides into diglycerides, monoglycerides, and free fatty acids. Notably, PLRP2 contains a PLAT domain, which facilitates protein-lipid interactions, enhancing lipolytic activity. This activity is particularly important as PLRP2 is inhibited by the lipase inhibitor orlistat, highlighting PLRP2′s relevance in metabolic processes and potential implications in obesity and related disorders. PLRP2′s ability to catalyze the reaction of triacylglycerol and water to form diacylglycerol and a carboxylate underscores functional importance in lipid digestion and absorption, making anti-PLRP2 antibody (D-1) a valuable tool for researchers studying lipid metabolism and related diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PLRP2 Antibody (D-1) References:
- Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity. | Giller, T., et al. 1992. J Biol Chem. 267: 16509-16. PMID: 1379598
- Human pancreatic lipase-related protein 2 is a galactolipase. | Sias, B., et al. 2004. Biochemistry. 43: 10138-48. PMID: 15287741
- Pancreatic lipase and pancreatic lipase-related protein 2, but not pancreatic lipase-related protein 1, hydrolyze retinyl palmitate in physiological conditions. | Reboul, E., et al. 2006. Biochim Biophys Acta. 1761: 4-10. PMID: 16497549
- Human pancreatic lipase-related protein 2: tissular localization along the digestive tract and quantification in pancreatic juice using a specific ELISA. | Eydoux, C., et al. 2006. Biochim Biophys Acta. 1760: 1497-504. PMID: 16887271
- Leptin directly regulates exocrine pancreas lipase and two related proteins in the rat. | Elinson, N., et al. 2006. Br J Nutr. 96: 691-6. PMID: 17010228
- Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family. | Aoki, J., et al. 2007. Biochimie. 89: 197-204. PMID: 17101204
- Further biochemical characterization of human pancreatic lipase-related protein 2 expressed in yeast cells. | Eydoux, C., et al. 2007. J Lipid Res. 48: 1539-49. PMID: 17401110
- Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation. | Eydoux, C., et al. 2008. Biochemistry. 47: 9553-64. PMID: 18702514
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PLRP2 Antibody (D-1) | sc-376236 | 200 µg/ml | $322.00 | |||
PLRP2 Antibody (D-1): m-IgG Fc BP-HRP Bundle | sc-529841 | 200 µg Ab; 10 µg BP | $361.00 | |||
PLRP2 Antibody (D-1): m-IgGκ BP-HRP Bundle | sc-522885 | 200 µg Ab, 40 µg BP | $361.00 | |||
PLRP2 Antibody (D-1) AC | sc-376236 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PLRP2 Antibody (D-1) HRP | sc-376236 HRP | 200 µg/ml | $322.00 | |||
PLRP2 Antibody (D-1) FITC | sc-376236 FITC | 200 µg/ml | $336.00 | |||
PLRP2 Antibody (D-1) PE | sc-376236 PE | 200 µg/ml | $349.00 | |||
PLRP2 Antibody (D-1) Alexa Fluor® 488 | sc-376236 AF488 | 200 µg/ml | $364.00 | |||
PLRP2 Antibody (D-1) Alexa Fluor® 546 | sc-376236 AF546 | 200 µg/ml | $364.00 | |||
PLRP2 Antibody (D-1) Alexa Fluor® 594 | sc-376236 AF594 | 200 µg/ml | $364.00 | |||
PLRP2 Antibody (D-1) Alexa Fluor® 647 | sc-376236 AF647 | 200 µg/ml | $364.00 | |||
PLRP2 Antibody (D-1) Alexa Fluor® 680 | sc-376236 AF680 | 200 µg/ml | $364.00 | |||
PLRP2 Antibody (D-1) Alexa Fluor® 790 | sc-376236 AF790 | 200 µg/ml | $364.00 |