Platelet IIb/IIIa complex Antibody (189/21-10): sc-53417

Platelet IIb/IIIa complex Antibody (189/21-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Platelet IIb and Platelet IIIa proteins of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Platelet IIb/IIIa complex antibody (189/21-10) specifically recognizes an epitope of the Fibrinogen receptor, which is crucial for platelet aggregation and hemostasis. This receptor is a member of the integrin family, composed of two glycoprotein subunits, Integrin α2b and Integrin β3, that form a heterodimeric complex known as glycoprotein complex IIb/IIIa. The Fibrinogen receptor not only facilitates the binding of fibrinogen, which is essential for platelet aggregation, but also serves as a receptor for von Willebrand factor and Fibronectin, further enhancing its role in the coagulation cascade. The structural integrity of this receptor is vital, as mutations or dysfunctions can lead to conditions such as thrombasthenia, characterized by impaired platelet function and increased bleeding risk. Platelet IIb/IIIa complex (189/21-10) antibody is highly specific for human platelets and does not cross-react with monocytes, leukocytes, lymphocytes, erythrocytes, leukemic cell lines, or fibroblast cell lines, making this monoclonal antibody an invaluable tool for research in hematology and cardiovascular studies.

The preferred Platelet IIb/IIIa complex antibody is Platelet IIb/IIIa complex Antibody (85/661): sc-73544.