Platelet IIb/IIIa complex Antibody (85/661): sc-73544

Platelet IIb/IIIa complex Antibody (85/661) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Platelet IIb/IIIa complex protein of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Platelet IIb/IIIa complex antibody (85/661) is available as a non-conjugated format. Platelet IIb/IIIa complex (85/661) antibody specifically recognizes an epitope of the Fibrinogen receptor, which is unique to platelets and does not cross-react with monocytes, leukocytes, lymphocytes, erythrocytes, leukemic cell lines, or fibroblast cell lines. The Fibrinogen receptor, also known as glycoprotein complex IIb/IIIa, is a critical component of the integrin family, composed of two subunit glycoproteins: Integrin α2b and Integrin β3, which form a heterodimeric complex in a 1:1 stoichiometric ratio. This receptor is essential for platelet aggregation and plays a vital role in hemostasis by facilitating the binding of platelets to fibrinogen and von Willebrand factor, thereby promoting clot formation. The structural integrity of the Fibrinogen receptor is crucial, as mutations or dysfunctions can lead to conditions such as thrombasthenia, characterized by impaired platelet aggregation and increased bleeding risk. Understanding the structure and function of the Platelet IIb/IIIa complex is important for developing therapeutic strategies targeting platelet function in various cardiovascular diseases.

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Platelet IIb/IIIa complex Antibody (85/661) References:

1. Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors.  |  Pytela, R., et al. 1986. Science. 231: 1559-62. PMID: 2420006
2. Isolation of the human platelet glycoprotein IIb gene and characterization of the 5' flanking region.  |  Prandini, MH., et al. 1988. Biochem Biophys Res Commun. 156: 595-601. PMID: 2845986
3. Biogenesis of the platelet receptor for fibrinogen: evidence for separate precursors for glycoproteins IIb and IIIa.  |  Bray, PF., et al. 1986. Proc Natl Acad Sci U S A. 83: 1480-4. PMID: 3006053
4. Immunochemical characterization of a new platelet specific monoclonal antibody and its use to demonstrate the cytoskeletal association of the platelet glycoprotein IIb-IIIa complex.  |  Bird, C., et al. 1986. Biosci Rep. 6: 323-33. PMID: 3015276
5. Platelet membrane glycoprotein IIb-IIIa complex incorporated into phospholipid vesicles. Preparation and morphology.  |  Parise, LV. and Phillips, DR. 1985. J Biol Chem. 260: 1750-6. PMID: 3155739
6. Physical linkage of the genes for platelet membrane glycoproteins IIb and IIIa.  |  Bray, PF., et al. 1988. Proc Natl Acad Sci U S A. 85: 8683-7. PMID: 3186752

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Platelet IIb/IIIa complex Antibody (85/661) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Platelet IIb/IIIa complex Antibody (85/661) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Platelet IIb/IIIa complex Antibody (85/661) Specifications

Alternate Product Name: Platelet IIb/IIIa complex

Product Clone Name: 85/661

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: Platelet IIb/IIIa complex

Epitope Species: human

Product Reactivity/Detection: Platelet IIb and Platelet IIIa

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Platelet IIb/IIIa complex Antibody (85/661): N/A